Hassan Ahmed K, Ameen Suhaam T, Saad Bahruddin, Al-Aragi Suad M
Department of Chemistry, College of Science, Baghdad University, Baghdad, Iraq.
Anal Sci. 2009 Nov;25(11):1295-9. doi: 10.2116/analsci.25.1295.
Trifluoperazine is widely used in the treatment of psychotic patients for its neuroleptic and antidepressive action. In this study, the construction, evaluation and application of new potentiometric sensors for trifluoperazine hydrochloride (TFPH) are described. The sensing membranes incorporated either ion-pair complexes of the trifluoperazine cation and phosphotungstic acid (PTA) or phosphomolybdic acid (PMA) or sodium tetraphenyl borate (NaTPB) as electroactive materials in poly(vinyl chloride) matrix membrane. The plasticizers used were di-n-butyl phthalate (DBPH) and tri-n-butyl phosphate (TBP). After a series of experiments, the best electrodes were based on PTA or PMA as electroactive materials and DBPH as plasticizer. A linear concentration range between 1 x 10(-5)-1 x 10(-2) M with a near Nernstian slope of 28.43 and 32.11 mV decade(-1), respectively, was obtained. The electrodes were characterized in terms of the composition, usable pH range, life span and response time. The selectivity coefficient values were calculated for different inorganic cations and sugars. Validation of the method shows the suitability of the electrodes for the determination of TFPH in pharmaceutical formulations.
三氟拉嗪因其抗精神病和抗抑郁作用而广泛用于治疗精神病患者。本研究描述了用于盐酸三氟拉嗪（TFPH）的新型电位传感器的构建、评估和应用。传感膜在聚氯乙烯基质膜中掺入三氟拉嗪阳离子与磷钨酸（PTA）或磷钼酸（PMA）或四苯硼酸钠（NaTPB）的离子对配合物作为电活性材料。使用的增塑剂是邻苯二甲酸二正丁酯（DBPH）和磷酸三正丁酯（TBP）。经过一系列实验，最佳电极以PTA或PMA作为电活性材料，DBPH作为增塑剂。分别获得了1×10⁻⁵ - 1×10⁻² M的线性浓度范围，其斜率接近能斯特斜率，分别为28.43和32.11 mV/decade⁻¹。对电极进行了组成、可用pH范围、寿命和响应时间等方面的表征。计算了不同无机阳离子和糖类的选择性系数值。该方法的验证表明这些电极适用于测定药物制剂中的TFPH。
