Yang Yanli, Zhu Chenfu, Shen Jian, Hao Aiyou
School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P.R. China.
Anal Sci. 2009 Nov;25(11):1315-8. doi: 10.2116/analsci.25.1315.
A novel beta-cyclodextrin (beta-CD) derivative modified with a degradable and biocompatible oligo(lactic acid) (OLA) group, 6-oligo(lactic acid)cyclomaltoheptaose (6-OLA-beta-CD), was successfully synthesized and used as a chiral selector for the capillary electrophoretic (CE) resolution (R(s)) of several basic analytes. The primary purpose of the research was to explore the capability of the 6-OLA-beta-CD as a chiral selector for comparisons with beta-CD and HP-beta-CD. Substitution with the oligo(lactic acid) group at the sixth hydroxyl sites of the CD is aimed at influencing the magnitude and selectivity of the analyte-CD interactions. The chiral resolution was strongly influenced by the concentration of the CDs and buffer pH. The effects of the substitution degree (DS) and the chain length (n) of the 6-oligo(lactic acid) groups of 6-OLA-beta-CD on separations were also investigated.
一种新型的用可降解且生物相容的低聚乳酸（OLA）基团修饰的β-环糊精（β-CD）衍生物，即6-低聚乳酸环麦芽七糖（6-OLA-β-CD），已成功合成，并用作几种碱性分析物的毛细管电泳（CE）拆分（Rs）的手性选择剂。该研究的主要目的是探索6-OLA-β-CD作为手性选择剂与β-CD和HP-β-CD进行比较的能力。在CD的第六个羟基位点用低聚乳酸基团进行取代旨在影响分析物与CD相互作用的强度和选择性。手性拆分受到CD浓度和缓冲液pH值的强烈影响。还研究了6-OLA-β-CD的6-低聚乳酸基团的取代度（DS）和链长（n）对分离的影响。
