Korb Associates, Boston, MA 02215, USA.
Cornea. 2010 Jan;29(1):34-8. doi: 10.1097/ICO.0b013e3181ac9fd0.
To investigate the diurnal secretory characteristics of individual meibomian glands (MGs).
Ten subjects (4 females and 6 males) with healthy eyelid appearance and without dry eye symptoms were recruited (mean age = 23.8 +/- 1.8 years). Both right and left lower eyelids were marked in 3 places to locate 5 consecutive MGs in each third (temporal, central, and nasal) of the lower eyelid. A total of 15 MGs per eye were diagnostically expressed for 10 seconds on both right and left lower eyelids every 3 hours for 4 consecutive measurements over a 9-hour period.
Thirty-four percent of all tested MGs yielded liquid secretion at all measurements. Sixty-nine percent of the tested nasal MGs yielded liquid secretion at all measurements in contrast to 31% of the central MGs and only 22% of the temporal MGs. The mean numbers of MGs secreting liquid oil were significantly higher in the nasal section relative to the central and temporal sections at all measurements (p < 0.001, all measurements).
(1) A single MG is capable of secreting oil on demand over the course of a working day ( approximately 9 hours); (2) nasal MGs were the most likely to secrete upon demand over the course of day compared with the temporal and to a lesser degree the central MGs; and (3) secretory characteristics of individual MGs examined as a function of their location in the lower eyelid does not change diurnally.
研究单个睑板腺（MGs）的昼夜分泌特征。
招募了 10 名（4 名女性和 6 名男性）具有健康眼睑外观且无干眼症状的受试者（平均年龄= 23.8 +/- 1.8 岁）。在右眼和左眼的下眼睑的 3 个位置标记右下眼睑的 3 个部位，以定位每个下眼睑的第 3 （颞，中，鼻）部分的 5 个连续的 MGs。每只眼的总共 15 个 MG 在右眼和左眼的下眼睑上进行 10 秒钟的诊断性表达，每 3 小时进行 4 次连续测量，共进行 9 小时。
在所有测试的 MG 中，有 34％的 MG 会产生液体分泌物。与中央 MG 的 31％和颞 MG 的仅 22％相比，69％的测试鼻 MG 在所有测量中都产生液体分泌物。在所有测量中，分泌液体油的 MG 数量在鼻段明显高于中央段和颞段（p <0.001，所有测量）。
（1）单个 MG 在工作日（约 9 小时）内可以按需分泌油；（2）与颞 MG 相比，鼻 MG 在白天更有可能按需分泌，程度稍差于中央 MG；（3）作为其在眼睑下位置的函数检查的个体 MG 的分泌特征不会随昼夜变化而变化。
