Osteoporosis and Bone Biology Program, Garvan Institute of Medical Research, St. Vincent's Hospital, Sydney, New South Wales, Australia.
Curr Opin Endocrinol Diabetes Obes. 2010 Feb;17(1):44-50. doi: 10.1097/MED.0b013e3283344a05.
To outline recent developments in research surrounding gastrointestinal peptides and their role in skeletal regulation.
Bone remodeling is influenced by many regulatory systems, which interact to ensure that the complex demands upon mineralized tissue are met without undue compromise. These include local actions such as mechanical factors, but are dominated by systemic endocrine factors. Although the involvement of hypothalamo-pituitary actions on bone homeostasis is well defined, growing evidence suggests that peripheral tissues and the circulating factors they produce represent an important regulatory axis in bone. Given the critical role of diet in mineral homeostasis, the gastrointestinal tract is a rich source of circulating factors capable of regulating bone homeostasis. After a review of manuscripts on known mechanisms and effects of gastrointestinal peptide on bone, these were summarized.
Although clearly an exciting and emergent field of research, more studies are required to define the specific actions of gastrointestinal regulator in bone, in particular, the relative contribution of systemic and local effects, to aid interpretation of their potential impact on human health and disease. Nonetheless, this exciting research will further our understanding on bone physiology and provide novel approaches to therapy in a wide range of skeletal conditions.
概述胃肠道肽及其在骨骼调节中的作用的研究进展。
骨重塑受许多调节系统的影响，这些系统相互作用以确保满足对矿化组织的复杂需求，而不会造成不必要的损害。这些包括局部作用，如机械因素，但主要受全身内分泌因素的影响。尽管下丘脑-垂体对骨稳态的作用已得到很好的定义，但越来越多的证据表明，外周组织及其产生的循环因子是骨的重要调节轴。鉴于饮食对矿物质稳态的重要性，胃肠道是循环因子的丰富来源，这些因子能够调节骨稳态。在回顾了关于胃肠道肽对骨骼的已知作用机制和影响的文献后，对这些作用机制和影响进行了总结。
尽管这显然是一个令人兴奋和新兴的研究领域，但仍需要更多的研究来定义胃肠道调节剂在骨骼中的具体作用，特别是全身和局部作用的相对贡献，以帮助解释它们对人类健康和疾病的潜在影响。尽管如此，这项令人兴奋的研究将增进我们对骨骼生理学的理解，并为广泛的骨骼疾病提供新的治疗方法。
