Division of Cancer Epidemiology, McGill University, Montréal, QC, Canada.
Epidemiology. 2010 Jan;21(1):31-7. doi: 10.1097/EDE.0b013e3181c1e70b.
No studies have examined human papillomavirus (HPV) infections among couples early in their sexual relationships when transmission is most likely. Our objective was to describe the distribution of HPV infections among recently formed couples, using the partnership as the unit of analysis.
Women aged 18-24 years attending a university or junior college in Montreal enrolled in a longitudinal study with their new male partners. Self-collected vaginal swabs and clinician-collected swabs from the penis and scrotum were tested for 36 HPV genotypes. Participants self-reported sexual behavior in computerized questionnaires. We analyzed patterns of genital HPV infection in 263 couples using data obtained at enrollment.
Couples had engaged in vaginal sex for a median of 3.9 months. HPV was detected in 64% (169/263) of couples. In 41% (109/263), both partners harbored the same HPV type-nearly 4 times more than expected if HPV status of partners were uncorrelated. There were 583 type-specific HPV infections among 169 couples for whom at least one partner was infected. Of these, 42% were of the same type for both partners (95% confidence interval = 36%-47%). This rose from 25% among those engaging in vaginal sex for less than 2 months to 68% among those at 5 to 6 months.
Although HPV is common, detection of the same type in persons initiating a sex relationship would be rare given type-specific prevalence rates. The high degree of concordance we found suggests a high probability of transmission.
目前尚无研究针对性伴侣关系早期（最易发生传播的阶段）的 HPV 感染情况进行分析。我们的目的是以伴侣关系为分析单位，描述刚建立性伴侣关系人群中 HPV 感染的分布情况。
18-24 岁的女性在蒙特利尔的一所大学或大专院校参加一项纵向研究，与新的男性伴侣一起参加。参与者自行采集阴道拭子，由临床医生采集阴茎和阴囊拭子，共检测 36 种 HPV 基因型。参与者在计算机化问卷中自我报告性行为。我们使用在入组时获得的数据，对 263 对情侣进行了生殖器 HPV 感染模式分析。
夫妻发生阴道性交的中位时间为 3.9 个月。64%（169/263）的夫妻 HPV 呈阳性。41%（109/263）的夫妻感染了相同的 HPV 类型——这几乎是伴侣 HPV 状态不相关时预期值的 4 倍。在至少有一名伴侣感染 HPV 的 169 对夫妻中，共发现 583 种 HPV 感染。其中，42%（95%置信区间=36%-47%）的夫妻感染了相同类型的 HPV。这种情况从性交时间少于 2 个月的夫妻中 25%上升到性交时间为 5-6 个月的夫妻中 68%。
尽管 HPV 很常见，但考虑到 HPV 类型的特定流行率，在刚开始性生活的人身上检测到相同类型的 HPV 是罕见的。我们发现的高度一致性表明，传播的可能性很高。
