Wilson P W, Cupples L A, Kannel W B
Framingham Heart Study, MA 01701.
Am Heart J. 1991 Feb;121(2 Pt 1):586-90. doi: 10.1016/0002-8703(91)90729-2.
The association of nonfasting blood glucose levels with CVD incidence was determined prospectively in 1382 men and 2094 women aged 45 to 84 years participating in the Framingham Heart Study. For this study, all patients were classified in 1970 as diabetic or nondiabetic. Every 2 years they were examined, categorized according to causal blood glucose samples obtained at the clinic visit, reclassified for development of CVD and diabetes mellitus, and followed 10 years for CVD. During the follow-up period, 350 men and 369 women developed CVD. Age-adjusted CVD rates were positively associated with glucose levels in nondiabetic women who did not develop diabetes during follow-up. No such associations were seen in men. Multivariate analyses confirmed the independent association of blood glucose levels with later CVD in nondiabetic women. This study shows that hyperglycemia in the original Framingham cohort is an independent risk factor for CVD in nondiabetic women, but not among men.
在参加弗雷明汉心脏研究的1382名年龄在45至84岁的男性和2094名女性中，前瞻性地确定了非空腹血糖水平与心血管疾病（CVD）发病率之间的关联。在这项研究中，所有患者在1970年被分类为糖尿病患者或非糖尿病患者。每两年对他们进行检查，根据在诊所就诊时采集的因果血糖样本进行分类，重新分类以确定是否发生CVD和糖尿病，并对CVD进行10年随访。在随访期间，350名男性和369名女性发生了CVD。在随访期间未患糖尿病的非糖尿病女性中，年龄调整后的CVD发病率与血糖水平呈正相关。在男性中未观察到此类关联。多变量分析证实了非糖尿病女性血糖水平与后期CVD之间的独立关联。这项研究表明，在最初的弗雷明汉队列中，高血糖是未患糖尿病女性发生CVD的独立危险因素，但在男性中并非如此。
