Department of Radiology, Shiga University of Medical Science, Shiga, Japan.
Cardiovasc Intervent Radiol. 2010 Feb;33(1):135-42. doi: 10.1007/s00270-009-9741-1. Epub 2009 Nov 12.
The purpose of this study was to evaluate pluronic F127 for the controlled release of cisplatin in a rabbit model. Pluronic F127 becomes liquid at temperatures <25 degrees C and converts to a gelatinous state at temperatures between 25 and 60 degrees C. Six Japanese white rabbits were injected with pluronic + cisplatin (n = 3, renal group A) or saline + cisplatin (n = 3, renal group B) to measure the platinum concentration in kidneys. Another 25 rabbits with VX2 liver tumors were divided into five equal groups. They were injected with saline, saline + cisplatin, iodized oil + cisplatin, pluronic alone, or pluronic + cisplatin and labeled as liver groups A, B, C, D, and E, respectively. The antitumor effect of pluronic was then assessed. In the presence of pluronic, the platinum concentration in the kidneys of rabbits remained relatively high. In animals with liver tumors, the delivery of pluronic + cisplatin produced higher tumor reduction rates (P < 0.05) than in the other groups, without apparent damage to normal liver tissue. We conclude that pluronic is useful for the controlled release of cisplatin in a rabbit model.
本研究旨在评估 Pluronic F127 对顺铂在兔模型中的控释作用。Pluronic F127 在温度<25°C 时呈液态，在 25°C 至 60°C 之间变为凝胶状。6 只日本大白兔分别注射 Pluronic+顺铂（n=3，肾组 A）或生理盐水+顺铂（n=3，肾组 B），以测量肾脏中的铂浓度。另外 25 只患有 VX2 肝癌的兔子被分为 5 组，分别注射生理盐水、生理盐水+顺铂、碘油+顺铂、Pluronic 及 Pluronic+顺铂，并标记为肝组 A、B、C、D 和 E。然后评估 Pluronic 的抗肿瘤作用。在 Pluronic 的存在下，兔肾中的铂浓度保持相对较高。在患有肝肿瘤的动物中，Pluronic+顺铂的递送产生了更高的肿瘤缓解率（P<0.05），而对正常肝组织没有明显损害。我们得出结论，Pluronic 可用于兔模型中顺铂的控释。
