姜黄素通过上调 MCF-7 细胞中 miR-15a 和 miR-16 的表达来降低 Bcl-2 的表达。
Curcumin reduces the expression of Bcl-2 by upregulating miR-15a and miR-16 in MCF-7 cells.
机构信息
Department of Nephrology, Tangdu Hospital, and Department of Immunology, The Fourth Military Medical University, Xi'an, Shaanxi Province, China.
出版信息
Med Oncol. 2010 Dec;27(4):1114-8. doi: 10.1007/s12032-009-9344-3. Epub 2009 Nov 12.
The medicinal properties of curcumin are well documented in Indian and Chinese systems of medicine, which refer to its wide use in the treatment of some diseases. It has shown to have anti-carcinogenic properties and is known to prevent tumor development in some cancers. In our study, we confirmed that the expression of miR-15a and miR-16 was upregulated and that of Bcl-2 was downregulated in curcumin-treated MCF-7 cells. Silencing miR-15a and miR-16 by specific inhibitors restored the expression of Bcl-2. Thus, we concluded that curcumin can reduce the expression of Bcl-2 by upregulating the expression of miR-15a and miR-16 in MCF-7 cells.
姜黄素的药用特性在印度和中国医学体系中有充分的记载，这两个医学体系都提到了它在治疗某些疾病方面的广泛应用。它已被证明具有抗癌特性，并已知可预防某些癌症中的肿瘤发展。在我们的研究中，我们证实姜黄素处理的 MCF-7 细胞中 miR-15a 和 miR-16 的表达上调，而 Bcl-2 的表达下调。通过特异性抑制剂沉默 miR-15a 和 miR-16 恢复了 Bcl-2 的表达。因此，我们得出结论，姜黄素可以通过上调 MCF-7 细胞中 miR-15a 和 miR-16 的表达来降低 Bcl-2 的表达。
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