果糖-山梨糖醇摄入会引发进食障碍患者的胃肠道症状。
Fructose-sorbitol ingestion provokes gastrointestinal symptoms in patients with eating disorders.
机构信息
Department of Obstetrics and Gastroenterology, Royal North Shore Hospital, University of Sydney, Sydney 2065, Australia.
出版信息
World J Gastroenterol. 2009 Nov 14;15(42):5295-9. doi: 10.3748/wjg.15.5295.
AIM
To evaluate gastrointestinal (GI) symptoms and breath hydrogen responses to oral fructose-sorbitol (F-S) and glucose challenges in eating disorder (ED) patients.
METHODS
GI symptoms and hydrogen breath concentration were monitored in 26 female ED inpatients for 3 h, following ingestion of 50 g glucose on one day, and 25 g fructose/5 g sorbitol on the next day, after an overnight fast on each occasion. Responses to F-S were compared to those of 20 asymptomatic healthy females.
RESULTS
F-S provoked GI symptoms in 15 ED patients and one healthy control (P<0.05 ED vs control). Only one ED patient displayed symptom provocation to glucose (P<0.01 vs F-S response). A greater symptom response was observed in ED patients with a body mass index (BMI)<or=17.5 kg/m2 compared to those with a BMI>17.5 kg/m2 (P<0.01). There were no differences in psychological scores, prevalence of functional GI disorders or breath hydrogen responses between patients with and without an F-S response.
CONCLUSION
F-S, but not glucose, provokes GI symptoms in ED patients, predominantly those with low BMI. These findings are important in the dietary management of ED patients.
目的
评估饮食失调（ED）患者口服果糖-山梨醇（F-S）和葡萄糖后胃肠道（GI）症状和呼气氢反应。
方法
26 名女性 ED 住院患者在禁食过夜后，每天分别摄入 50 g 葡萄糖和 25 g 果糖/5 g 山梨醇，在接下来的 3 小时内监测 GI 症状和氢呼气浓度。将 F-S 的反应与 20 名无症状健康女性的反应进行比较。
结果
F-S 引起 15 名 ED 患者和 1 名健康对照者出现 GI 症状（P<0.05 ED 与对照组）。只有 1 名 ED 患者对葡萄糖表现出症状诱发（P<0.01 与 F-S 反应相比）。与 BMI>17.5 kg/m2 的患者相比，BMI<or=17.5 kg/m2 的 ED 患者出现更大的症状反应（P<0.01）。在有和没有 F-S 反应的患者之间，心理评分、功能性 GI 障碍的患病率或呼气氢反应没有差异。
结论
F-S 而不是葡萄糖，会引起 ED 患者的 GI 症状，主要是 BMI 较低的患者。这些发现对 ED 患者的饮食管理很重要。
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