Jayakumar Onattu Damodharan, Ganguly Rajib, Tyagi Avesh Kumar, Chandrasekharan Dhanya K, Nair Cherupally K Krishnan
Chemistry Division, Bhabha Atomic Research Centre, Mumbai 400085, India.
J Nanosci Nanotechnol. 2009 Nov;9(11):6344-8. doi: 10.1166/jnn.2009.1369.
Water dispersible Fe3O4 nanoparticles (coated with Poly Vinyl Pyrolidone (PVP) and Poly oxy ethylene 25-propylene glycol stearate (POES)) and complexed with Doxorubicin has been prepared and characterized using X-ray diffraction (XRD), transmission electron microscopy (TEM) and vibrating sample magnetometer (VSM). The antitumor activity of these particles has been studied by targeting the complex to the tumor site, using an externally applied magnetic field, after oral administration of the magnetic nanoparticle-drug complexes. Our results reveal that the chemotherapy effect of Doxorubicin could be considerably enhanced by combination of the application of the drug-conjugated magnetic Fe3O4 nanoparticles, which are biocompatible and stable, and targeted drug delivery with a magnet. The present report provides the first evidence for the promising application of this novel approach with PVP coated Fe3O4 nanoparticles for cancer therapy using an in vivo murine model.
已制备了水分散性四氧化三铁纳米颗粒（包覆有聚乙烯吡咯烷酮（PVP）和聚氧乙烯25-丙二醇硬脂酸酯（POES））并使其与阿霉素络合，使用X射线衍射（XRD）、透射电子显微镜（TEM）和振动样品磁强计（VSM）对其进行了表征。在口服磁性纳米颗粒-药物络合物后，利用外部施加的磁场将该络合物靶向肿瘤部位，研究了这些颗粒的抗肿瘤活性。我们的结果表明，通过将药物共轭磁性四氧化三铁纳米颗粒（具有生物相容性且稳定）与磁靶向药物递送相结合，阿霉素的化疗效果可得到显著增强。本报告首次提供了证据，证明这种用PVP包覆的四氧化三铁纳米颗粒的新方法在体内小鼠模型用于癌症治疗具有广阔的应用前景。
