Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois, Chicago, Chicago, Illinois 60612, USA.
AIDS Patient Care STDS. 2009 Dec;23(12):1009-16. doi: 10.1089/apc.2009.0175.
Since the introduction of highly active antiretroviral therapy (HAART) and the subsequent increased life expectancy in HIV-infected persons, non-HIV-related diseases have become an important cause of morbidity and mortality. This cross-sectional study reports the prevalence of overweight and obesity, and sociodemographic, psychological, and substance use-related risk factors for elevated body mass index (BMI) among 2157 HIV-seropositive (HIV+) in comparison to 730 HIV-seronegative (HIV-) participants in the Women's Interagency HIV Study (WIHS). Separate univariable and multivariate linear regression analyses were completed for HIV+ and HIV- women. Our study revealed a similar proportion of obesity (body mass index [BMI] >or=30) among HIV+ (33%) and HIV- women (29%) (p = 0.12), as well as comparable median BMI (HIV+: 26.1 versus HIV-: 26.7, p = 0.16). HIV+ compared to HIV- women, respectively, were significantly (p < 0.01) older (median = 35.6 versus. 32.5), but similar (p = 0.97) by race/ethnicity (57% African American, 28% Hispanic, and 15% white for both). In multivariate models for both HIV+ and HIV- women, African American race/ethnicity was significantly (p < 0.05) associated with higher BMI, while higher quality of life score and illicit hard drug use were associated with lower BMI. Additionally, smoking, alcohol use, markers of advanced HIV infection (AIDS diagnosis, elevated HIV viral load, low CD4 count), and a history of antiretroviral therapy use (ART) were also associated with lower BMI among HIV+ women. In conclusion, risk factors for elevated BMI were similar for HIV+ and HIV- women in the WIHS. For HIV+ women, all markers of advanced HIV infection and ART use were additionally associated with lower BMI.
自从引入高效抗逆转录病毒疗法（HAART）以及随后感染艾滋病毒者预期寿命的延长以来，非艾滋病毒相关疾病已成为发病率和死亡率的重要原因。这项横断面研究报告了在妇女艾滋病病毒研究机构间研究（WIHS）中，与 730 名 HIV 阴性（HIV-）参与者相比，2157 名 HIV 阳性（HIV+）者中超重和肥胖的流行情况，以及与社会人口统计学，心理和物质使用相关的身体质量指数（BMI）升高的危险因素。对 HIV+和 HIV-女性分别完成了单变量和多变量线性回归分析。我们的研究表明，HIV+（33％）和 HIV-女性（29％）肥胖（BMI≥30）的比例相似（p = 0.12），且中位数 BMI 相似（HIV+：26.1 与 HIV-：26.7，p = 0.16）。与 HIV-女性相比，HIV+女性分别明显更年长（中位数= 35.6 与 32.5，p <0.01），但种族/族裔（57％为非裔美国人，28％为西班牙裔，两者均为 15％）相似（p = 0.97）。在针对 HIV+和 HIV-女性的多变量模型中，非裔美国人种族/族裔与更高的 BMI 显著相关（p <0.05），而较高的生活质量评分和非法使用硬毒品与较低的 BMI 相关。此外，吸烟，饮酒，艾滋病毒感染（艾滋病诊断，HIV 病毒载量升高，CD4 计数低）的先进标志物以及抗逆转录病毒疗法（ART）的使用史也与 HIV+女性的 BMI 降低相关。总之，WIHS 中 HIV+和 HIV-女性的 BMI 升高的危险因素相似。对于 HIV+女性，所有艾滋病毒感染和 ART 使用的先进标志物均与 BMI 降低有关。
