Becofsky Katie M, Wing Edward J, Wing Rena R, Richards Kathryn E, Gillani Fizza S
Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, USA.
Weight Control and Diabetes Research Center, The Miriam Hospital, Providence, RI, USA.
Obes Sci Pract. 2016 Jun;2(2):123-127. doi: 10.1002/osp4.38. Epub 2016 May 31.
Human immunodeficiency virus infection and obesity are pro-inflammatory conditions that, when occurring together, may pose a synergistic risk for diabetes and cardiovascular disease.
The aim of the current study was (i) to document the prevalence of obesity in HIV+ patients treated at the Miriam Hospital Immunology Center (Providence, RI) and (ii) to investigate the relationship between obesity and comorbidities.
The study population consisted of 1,489 HIV+ adults (70% men; average age 48 ± 11 years) treated between 01/01/2012 and 06/30/2014. Separate logistic regressions tested the associations between overweight and obesity and comorbid diagnoses (diabetes, hypertension and cardiovascular disease), as compared with normal weight. Covariates included age, gender and smoking status.
Approximately 37% of patients were overweight (body mass index 25.0-29.9), and an additional 28% were obese (body mass index ≥30.0). Obesity was associated with higher odds of comorbid diabetes (OR = 3.26, CI = 1.98-5.39) and hypertension (OR = 2.11, CI = 1.49-2.98). There was no significant association between obesity and the presence of cardiovascular disease (OR = 1.12, CI = 0.66-1.90). Overweight was associated only with higher odds of comorbid diabetes (OR = 1.72; CI = 1.02-2.88).
Our findings demonstrate a heightened risk of comorbidities in overweight and obese HIV + patients. Future studies should investigate whether weight loss interventions for this population can reduce cardiovascular and metabolic risk factors as they do in other populations.
人类免疫缺陷病毒感染和肥胖均为促炎状态，二者共同出现时，可能会对糖尿病和心血管疾病构成协同风险。
本研究的目的是（i）记录在米里亚姆医院免疫中心（罗德岛州普罗维登斯）接受治疗的HIV阳性患者中肥胖的患病率，以及（ii）研究肥胖与合并症之间的关系。
研究人群包括2012年1月1日至2014年6月30日期间接受治疗的1489名HIV阳性成年人（70%为男性；平均年龄48±11岁）。与正常体重者相比，分别采用逻辑回归分析超重和肥胖与合并诊断（糖尿病、高血压和心血管疾病）之间的关联。协变量包括年龄、性别和吸烟状况。
约37%的患者超重（体重指数25.0 - 29.9），另有28%的患者肥胖（体重指数≥30.0）。肥胖与合并糖尿病（OR = 3.26，CI = 1.98 - 5.39）和高血压（OR = 2.11，CI = 1.49 - 2.98）的较高几率相关。肥胖与心血管疾病的存在之间无显著关联（OR = 1.12，CI = 0.66 - 1.90）。超重仅与合并糖尿病的较高几率相关（OR = 1.72；CI = 1.02 - 2.88）。
我们的研究结果表明超重和肥胖的HIV阳性患者合并症风险增加。未来的研究应调查针对该人群的体重减轻干预措施是否能像在其他人群中一样降低心血管和代谢风险因素。
