Department of Anatomy, MRC Centre for Synaptic Plasticity, University of Bristol, Bristol, UK.
Biochem Soc Trans. 2009 Dec;37(Pt 6):1359-63. doi: 10.1042/BST0371359.
Calcium entry plays a major role in the induction of several forms of synaptic plasticity in different areas of the central nervous system. The spatiotemporal aspects of these calcium signals can determine the type of synaptic plasticity induced, e.g. LTP (long-term potentiation) or LTD (long-term depression). A vast amount of research has been conducted to identify the molecular and cellular signalling pathways underlying LTP and LTD, but many components remain to be identified. Calcium sensor proteins are thought to play an essential role in regulating the initial part of synaptic plasticity signalling pathways. However, there is still a significant gap in knowledge, and it is only recently that evidence for the importance of members of the NCS (neuronal calcium sensor) protein family has started to emerge. The present minireview aims to bring together evidence supporting a role for NCS proteins in plasticity, focusing on emerging roles of NCS-1 and hippocalcin.
钙内流在中枢神经系统不同区域的几种形式的突触可塑性诱导中起主要作用。这些钙信号的时空方面可以决定诱导的突触可塑性的类型，例如 LTP（长时程增强）或 LTD（长时程抑制）。已经进行了大量研究来确定 LTP 和 LTD 的分子和细胞信号通路，但仍有许多成分有待确定。钙传感器蛋白被认为在调节突触可塑性信号通路的初始部分中发挥重要作用。然而，知识仍然存在巨大的差距，直到最近，才开始出现 NCS（神经元钙传感器）蛋白家族成员的重要性的证据。本综述旨在汇集支持 NCS 蛋白在可塑性中的作用的证据，重点介绍 NCS-1 和 hippocalcin 的新兴作用。
