补体成分 5 的单核苷酸多态性与牙周炎。
Single nucleotide polymorphisms of complement component 5 and periodontitis.
机构信息
Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.
出版信息
J Periodontal Res. 2010 Jun;45(3):301-8. doi: 10.1111/j.1600-0765.2009.01234.x. Epub 2009 Nov 9.
BACKGROUND AND OBJECTIVE
Polymorphisms of host defence genes might increase one's risks for periodontitis. This study investigated whether tagging single nucleotide polymorphisms (SNPs) of the gene encoding complement component 5 (C5) are associated with periodontitis in a Hong Kong Chinese population.
MATERIAL AND METHODS
Eleven tagging SNPs of 229 patients with at least moderate periodontitis and 207 control subjects without periodontitis were genotyped using an i-plexGOLD MassARRAY mass-spectrometry system.
RESULTS
Genotype AG of SNP rs17611 was more prevalent in the group of periodontitis patients than in the controls (54.6% vs. 41.7%, p = 0.007). The haplotype CGCA of the haplotype block consisting of rs1035029, rs17611, rs25681 and rs992670 was significantly associated with periodontitis in a dominant model (p = 0.001). The SNP rs17611 showed high linkage disequilibrium with rs1035029, rs25681 and rs992670. Smoking was also significantly associated with periodontitis (p = 0.006).
CONCLUSION
The tagging SNP rs17611 of the C5 gene and smoking may be associated with periodontitis among the Hong Kong Chinese population.
背景与目的
宿主防御基因的多态性可能会增加个体患牙周炎的风险。本研究旨在探讨编码补体成分 5（C5）的基因中的单核苷酸多态性（SNP）是否与香港华人的牙周炎有关。
材料与方法
采用 i-plexGOLD MassARRAY 质谱系统，对 229 名至少患有中度牙周炎的患者和 207 名无牙周炎的对照者的 11 个标签 SNP 进行基因分型。
结果
SNP rs17611 的 AG 基因型在牙周炎患者组中比对照组更为常见（54.6% vs. 41.7%，p=0.007）。由 rs1035029、rs17611、rs25681 和 rs992670 组成的单倍型块的 CGCA 单倍型在显性模型中与牙周炎显著相关（p=0.001）。SNP rs17611 与 rs1035029、rs25681 和 rs992670 高度连锁不平衡。吸烟也与牙周炎显著相关（p=0.006）。
结论
C5 基因的标签 SNP rs17611 和吸烟可能与香港华人的牙周炎有关。
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