Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.
J Periodontal Res. 2010 Jun;45(3):301-8. doi: 10.1111/j.1600-0765.2009.01234.x. Epub 2009 Nov 9.
Polymorphisms of host defence genes might increase one's risks for periodontitis. This study investigated whether tagging single nucleotide polymorphisms (SNPs) of the gene encoding complement component 5 (C5) are associated with periodontitis in a Hong Kong Chinese population.
Eleven tagging SNPs of 229 patients with at least moderate periodontitis and 207 control subjects without periodontitis were genotyped using an i-plexGOLD MassARRAY mass-spectrometry system.
Genotype AG of SNP rs17611 was more prevalent in the group of periodontitis patients than in the controls (54.6% vs. 41.7%, p = 0.007). The haplotype CGCA of the haplotype block consisting of rs1035029, rs17611, rs25681 and rs992670 was significantly associated with periodontitis in a dominant model (p = 0.001). The SNP rs17611 showed high linkage disequilibrium with rs1035029, rs25681 and rs992670. Smoking was also significantly associated with periodontitis (p = 0.006).
The tagging SNP rs17611 of the C5 gene and smoking may be associated with periodontitis among the Hong Kong Chinese population.
宿主防御基因的多态性可能会增加个体患牙周炎的风险。本研究旨在探讨编码补体成分 5（C5）的基因中的单核苷酸多态性（SNP）是否与香港华人的牙周炎有关。
采用 i-plexGOLD MassARRAY 质谱系统，对 229 名至少患有中度牙周炎的患者和 207 名无牙周炎的对照者的 11 个标签 SNP 进行基因分型。
SNP rs17611 的 AG 基因型在牙周炎患者组中比对照组更为常见（54.6% vs. 41.7%，p=0.007）。由 rs1035029、rs17611、rs25681 和 rs992670 组成的单倍型块的 CGCA 单倍型在显性模型中与牙周炎显著相关（p=0.001）。SNP rs17611 与 rs1035029、rs25681 和 rs992670 高度连锁不平衡。吸烟也与牙周炎显著相关（p=0.006）。
C5 基因的标签 SNP rs17611 和吸烟可能与香港华人的牙周炎有关。
