Lieberman J, Rea T H
Ann Intern Med. 1977 Oct;87(4):423-5. doi: 10.7326/0003-4819-87-4-422.
Serum angiotensin-converting enzyme levels were found to be elevated in 71.4% of 42 leprosy patients, both treated and untreated, but in only one of 13 patients with disseminated coccidioidomycosis. The elevations with leprosy were present in association with each of the three major categories: lepromatous, borderline, or tuberculoid. Sulfone therapy had no immediate effect on the elevated serum levels, although long-term sulfone therapy appeared to result in lowering of the level. Corticosteroid therapy had a more immediate and dramatic effect on reducing the elevated angiotensin-converting enzyme level in leprosy. This assay cannot distinguish between sarcoidosis and leprosy or between the various categories of leprosy, but it can help differentiate sarcoidosis from fungal or tuberculous disease. Elevated levels of serum angiotensin-converting enzyme have now been associated with three diseases states: sarcoidosis, Gaucher's disease, and leprosy.
在42例麻风患者（包括接受治疗和未接受治疗的）中，71.4%的患者血清血管紧张素转换酶水平升高，但在13例播散性球孢子菌病患者中只有1例升高。麻风患者中血管紧张素转换酶水平升高与三种主要类型（瘤型、界线类或结核样型）均有关。砜类疗法对血清水平升高无即刻影响，尽管长期砜类疗法似乎可使水平降低。皮质类固醇疗法对降低麻风患者升高的血管紧张素转换酶水平有更迅速且显著的效果。该检测无法区分结节病和麻风，也无法区分麻风的不同类型，但有助于将结节病与真菌或结核疾病区分开来。血清血管紧张素转换酶水平升高目前已与三种疾病状态相关：结节病、戈谢病和麻风。
