Kuenstner J Todd, Chamberlin William, Naser Saleh A, Collins Michael T, Dow Coad Thomas, Aitken John M, Weg Stuart, Telega Grzegorz, John Kuruvilla, Haas David, Eckstein Torsten M, Kali Maher, Welch Christine, Petrie Thomas
J Todd Kuenstner, Department of Pathology, Charleston Area Medical Center, Charleston, WV 25304, United States.
World J Gastroenterol. 2015 Apr 7;21(13):4048-62. doi: 10.3748/wjg.v21.i13.4048.
A cohort of family members with various chronic diseases including Crohn's disease, asthma, complex regional pain syndrome, hypothyroidism, type 1 diabetes mellitus, and lymphangiomatosis and/or evidence of infection by Mycobacterium avium subsp. paratuberculosis (MAP) are described in this series of case reports. MAP was cultured from the blood of three members affected by the first five diseases and there was accompanying elevated anti-MAP IgG in two members. The patient affected by the sixth disease has a markedly elevated anti-MAP titer. The two patients affected by the first four diseases have been treated with a combination of anti-MAP antibiotics and ultraviolet blood irradiation therapy with resolution of the disease symptomatology and inability to culture MAP in post treatment blood samples. These case reports of patients with MAP infections provide supportive evidence of a pathogenic role of MAP in humans.
在这一系列病例报告中，描述了一组患有各种慢性疾病的家庭成员，这些疾病包括克罗恩病、哮喘、复杂性区域疼痛综合征、甲状腺功能减退、1型糖尿病以及淋巴管瘤病，和/或存在副结核分枝杆菌（MAP）感染的证据。在前五种疾病的三名患者血液中培养出了MAP，并且在两名患者中伴有抗MAP IgG升高。患有第六种疾病的患者抗MAP滴度显著升高。前四种疾病的两名患者接受了抗MAP抗生素和紫外线血液照射疗法的联合治疗，疾病症状得到缓解，治疗后的血液样本中无法培养出MAP。这些MAP感染患者的病例报告为MAP在人类中的致病作用提供了支持性证据。
