Neuroscience Research Institute, Gachon University of Medicine and Science, Incheon 1198 Kuwol-dong, Namdong-gu, Incheon 405-760, Korea.
Neuroimage. 2010 Feb 1;49(3):2134-40. doi: 10.1016/j.neuroimage.2009.11.002. Epub 2009 Nov 10.
In-vivo volumetric measurements of hippocampus have proven to be highly informative for studying various neurological diseases such as Alzheimer's disease. The usefulness of volumetric imaging, however, has been limited due to the poor image resolutions obtained by currently available MRI images. In this study, a new result of volumetric image measurement of the hippocampus using 7.0 T MRI images of high contrast and resolution is described. To verify the usefulness of the proposed method, its reliability and sensitivity were examined and compared with existing imaging techniques such as 1.5 T or 3.0 T MRI imaging. The results of our study with 7.0 T MRI clearly demonstrated superior boundary detection for the hippocampal head, body, and tail compared with low field MRIs. In conclusion, robust and reproducible volumetric measurements as well as 3D images of clear contrast obtained with 7.0 T suggest the usefulness of high field MR imaging and its eventual use for the accurate diagnosis of hippocampal diseases and related research.
体内海马体容积测量已被证明对研究各种神经退行性疾病（如阿尔茨海默病）非常有价值。然而，由于目前可用的 MRI 图像的图像分辨率较差，容积成像的有用性受到限制。在这项研究中，描述了一种使用高对比度和高分辨率 7.0 T MRI 图像对海马体进行容积图像测量的新结果。为了验证该方法的有用性，检查了其可靠性和灵敏度，并与 1.5 T 或 3.0 T MRI 成像等现有成像技术进行了比较。我们使用 7.0 T MRI 的研究结果清楚地表明，与低场 MRI 相比，海马头、体和尾的边界检测更优。总之，使用 7.0 T 获得的可靠、可重复的容积测量以及清晰对比的 3D 图像表明，高磁场 MRI 成像具有有用性，并且可以最终用于准确诊断海马疾病和相关研究。
