Department of Internal Medicine, Wayne State University, Detroit, MI 48201, USA.
Infect Dis Clin North Am. 2009 Dec;23(4):965-82, ix. doi: 10.1016/j.idc.2009.06.010.
An overview of the mechanism of action, dosing, clinical indications, and toxicities of the glycopeptide vancomycin is provided. The emerging gram-positive bacterial resistance to antimicrobials and its mechanisms are reviewed. Strategies to control this emergence of resistance are expected to be proposed. Newer antimicrobial agents that have activity against vancomycin-resistant organisms are now available and play a critical role in the treatment of life-threatening infections.
提供了糖肽万古霉素的作用机制、剂量、临床适应证和毒性的概述。回顾了革兰氏阳性菌对抗微生物药物的耐药性及其机制。预计将提出控制这种耐药性出现的策略。现在有了对万古霉素耐药菌有活性的新型抗菌药物，在治疗危及生命的感染方面发挥着关键作用。
