Department of Ecology, Swedish University of Agricultural Sciences, 750-07 Uppsala, Sweden.
J Invertebr Pathol. 2010 Jan;103 Suppl 1:S30-47. doi: 10.1016/j.jip.2009.06.014. Epub 2009 Nov 11.
Acute bee paralysis virus (ABPV), Kashmir bee virus (KBV) and Israeli acute paralysis virus (IAPV) are part of a complex of closely related viruses from the Family Dicistroviridae. These viruses have a widespread prevalence in honey bee (Apis mellifera) colonies and a predominantly sub-clinical etiology that contrasts sharply with the extremely virulent pathology encountered at elevated titres, either artificially induced or encountered naturally. These viruses are frequently implicated in honey bee colony losses, especially when the colonies are infested with the parasitic mite Varroa destructor. Here we review the historical and recent literature of this virus complex, covering history and origins; the geographic, host and tissue distribution; pathology and transmission; genetics and variation; diagnostics, and discuss these within the context of the molecular and biological similarities and differences between the viruses. We also briefly discuss three recent developments relating specifically to IAPV, concerning its association with Colony Collapse Disorder, treatment of IAPV infection with siRNA and possible honey bee resistance to IAPV.
急性蜜蜂麻痹病毒（ABPV）、克什米尔蜜蜂病毒（KBV）和以色列急性麻痹病毒（IAPV）是来自双翅目病毒科的密切相关病毒群的一部分。这些病毒在蜜蜂（Apis mellifera）群体中广泛流行，具有主要亚临床病因，与在高滴度下遇到的极为毒力病理学形成鲜明对比，无论是人为诱导还是自然发生。这些病毒经常与蜜蜂群体损失有关，尤其是当群体受到寄生螨（Varroa destructor）的侵害时。在这里，我们回顾了该病毒群的历史和近期文献，涵盖了历史和起源；地理、宿主和组织分布；病理学和传播；遗传学和变异；诊断，并在病毒之间的分子和生物学相似性和差异的背景下讨论了这些问题。我们还简要讨论了与 IAPV 相关的三个最近进展，涉及到它与蜂群崩溃失调症的关联、使用 siRNA 治疗 IAPV 感染以及可能的蜜蜂对 IAPV 的抗性。
