School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada.
Obesity (Silver Spring). 2010 Jul;18(7):1336-40. doi: 10.1038/oby.2009.414. Epub 2009 Nov 12.
The associations between visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (ASAT) and metabolic risk may be influenced by measurement site. The aim of this study was to compare the strength of the associations between VAT and ASAT, as assessed by a cross-sectional image (area) or total volume, and prevalent metabolic syndrome (MetS). We also examined the association between changes in abdominal AT area and volume with concomitant changes in metabolic risk. Abdominal AT volume and areas were derived using ~35 continuous computed tomography (CT) images from T10-T11 to L5-S1 in overweight or obese postmenopausal women before (n = 67) and after (n = 39) a 6-month exercise intervention. At baseline, measurement site did not influence the inter-relationship between ASAT area and total volume, and between ASAT and MetS. Conversely, VAT areas at L1-L2 and L2-L3 were stronger correlates of VAT volume at baseline (L1-L2 (r = 0.94), L2-L3 (r = 0.95), L4-L5 (r = 0.89)) and changes therein (L1-L2 (r = 0.77), L2-L3 (r = 0.75), L4-L5 (r = 0.55)) as compared to L4-L5, but were not significantly better predictors of MetS as compared to L4-L5 or the total volume (L2-L3: odds ratio (OR) = 2.68 (1.6-4.4), L1-L2: OR = 1.88 (1.2-3.0), L4-L5: OR = 2.56 (1.6-4.1), volume: OR = 2.07 (1.1-3.8)). Changes in VAT and ASAT were not associated with changes in MetS (P > 0.10). Although measurement site has an impact on the prediction of VAT volume, this does not translate into an improved prediction for the MetS. Thus, there is not enough evidence to support changing the current research practice of assessing VAT volume or at L4-L5 for the prediction of metabolic risk.
内脏脂肪组织 (VAT) 和腹部皮下脂肪组织 (ASAT) 与代谢风险之间的关联可能受测量部位的影响。本研究旨在比较通过横断面图像 (面积) 或总体积评估的 VAT 和 ASAT 之间的关联强度，以及常见的代谢综合征 (MetS)。我们还研究了腹部脂肪组织面积和体积的变化与代谢风险的同时变化之间的关系。在超重或肥胖绝经后妇女进行 6 个月的运动干预前后 (n = 67 和 39)，使用 T10-T11 至 L5-S1 之间的约 35 个连续 CT 图像得出腹部脂肪组织体积和面积。在基线时，测量部位并不影响 ASAT 面积和总量之间的相互关系，以及 ASAT 与 MetS 之间的关系。相反，L1-L2 和 L2-L3 处的 VAT 面积是基线时 VAT 体积的更强相关因素 (L1-L2(r = 0.94)、L2-L3(r = 0.95)、L4-L5(r = 0.89)) 和其中的变化 (L1-L2(r = 0.77)、L2-L3(r = 0.75)、L4-L5(r = 0.55))，与 L4-L5 相比，但作为 MetS 的预测指标并不明显优于 L4-L5 或总体积 (L2-L3：比值比 (OR) = 2.68(1.6-4.4)，L1-L2：OR = 1.88(1.2-3.0)，L4-L5：OR = 2.56(1.6-4.1)，体积：OR = 2.07(1.1-3.8))。VAT 和 ASAT 的变化与 MetS 的变化无关 (P > 0.10)。尽管测量部位对 VAT 体积的预测有影响，但这并不转化为代谢风险预测的改善。因此，没有足够的证据支持改变目前评估 VAT 体积或 L4-L5 以预测代谢风险的研究实践。
