Marunowski Kacper, Świętoń Dominik, Bzyl Włodzimierz, Grzywińska Małgorzata, Kaszubowski Mariusz, Bandosz Piotr, Khrichenko Dmitry, Piskunowicz Maciej
Department of Radiology, Medical University of Gdańsk, Gdańsk, Poland.
Faculty of Mathematics, Physics and Informatics, University of Gdańsk, Gdańsk, Poland.
Front Nutr. 2021 Oct 1;8:757274. doi: 10.3389/fnut.2021.757274. eCollection 2021.
The assessment of body composition in pediatric population is essential for proper nutritional support during hospitalization. However, currently available methods have limitations. This study aims to propose a novel approach for nutrition status assessment and introduce magnetic resonance imaging (MRI)-derived subcutaneous and visceral fat normative reference values. A total of 262 healthy subjects aged from 6 to 18 years underwent MRI examinations and anthropometric measurements. MRI images at the second lumbar vertebrae were used by two radiologists to perform the semi-automatic tissue segmentation. Based on obtained adipose tissue surface areas and body mass index (BMI) scores sex-specific standard percentile curves (3rd, 10th, 25th, 50th, 75th, 90th, 97th) and z-scores were constructed using LMS method. Additionally, 85th and 95th centiles of subcutaneous and visceral adipose tissue were proposed as equivalents of overweight and obesity. Bland-Altman plots revealed an excellent intra-observer reproducibility and inter-observer agreement. In conclusion, our findings demonstrate highly reproducible method and suggest that MRI-derived reference values can be implemented in clinical practice.
评估儿科人群的身体成分对于住院期间适当的营养支持至关重要。然而，目前可用的方法存在局限性。本研究旨在提出一种新的营养状况评估方法，并引入磁共振成像（MRI）得出的皮下和内脏脂肪规范参考值。共有262名6至18岁的健康受试者接受了MRI检查和人体测量。两名放射科医生使用第二腰椎水平的MRI图像进行半自动组织分割。基于获得的脂肪组织表面积和体重指数（BMI）分数，使用LMS方法构建了按性别划分的标准百分位数曲线（第3、10、25、50、75、90、97百分位数）和z分数。此外，将皮下和内脏脂肪组织的第85和95百分位数作为超重和肥胖的等效指标。布兰德-奥特曼图显示了观察者内的高度可重复性和观察者间的一致性。总之，我们的研究结果证明了该方法具有高度可重复性，并表明MRI得出的参考值可应用于临床实践。
