Department of Family Medicine, College of Medicine, The Catholic University of Korea, 505 Banpo-Dong, Seocho-Gu, 137-701 Seoul, Republic of Korea.
Department of Family Medicine, College of Medicine, The Catholic University of Korea, 505 Banpo-Dong, Seocho-Gu, 137-701 Seoul, Republic of Korea.
Obes Res Clin Pract. 2010 Oct-Dec;4(4):e247-342. doi: 10.1016/j.orcp.2010.06.002.
Visceral adipose tissue (VAT) is presumed to play an important role in the development of metabolic syndrome (MS). The purpose of this study was to evaluate the influence of measurement location of VAT on the cardiometabolic risk factors and the MS in the Korean population.
To assess abdominal fat distribution, 5 single-slice computed tomography (CT) images were obtained in 470 healthy subjects. The five CT images were obtained at the intervertebral space from L1 to S1 using known anatomical landmarks. Multiple logistic regression analysis was performed to assess the relationship between regional adipose tissue areas and MS.
All risk factors were more closely correlated with VAT than subcutaneous adipose tissue (SAT), except waist circumference and blood pressure. Images located at L2-L3 or L3-L4 provided high correlations between VAT area and all cardiometabolic risk factors. The highest adjusted odds (per SD) between VAT and MS were the L2-L3 image in men (OR 4.53) and the L1-L2 in women (OR 4.87), which was higher than measures at L4-L5 (OR 3.22 in men, OR 4.71 in women). However, differences in OR between L1-L2 VAT (OR 4.87) and L4-L5 (OR 4.71) were not great in women.
The results of this study suggest that VAT has a stronger association with MS than ASAT in Korean population regardless of measurement site, and an image located in the upper abdomen (L2-L3 or L3-L4) would be a better predictor of the relationship between VAT and MS in Korean men.
内脏脂肪组织（VAT）被认为在代谢综合征（MS）的发展中起重要作用。本研究旨在评估 VAT 测量部位对韩国人群中心血管代谢危险因素和 MS 的影响。
为了评估腹部脂肪分布，在 470 名健康受试者中获得了 5 个单层面计算机断层扫描（CT）图像。这 5 个 CT 图像是使用已知的解剖学标志在 L1 到 S1 的椎间隙获得的。采用多变量逻辑回归分析评估区域脂肪组织面积与 MS 之间的关系。
所有危险因素与 VAT 的相关性均高于与皮下脂肪组织（SAT）的相关性，除腰围和血压外。位于 L2-L3 或 L3-L4 的图像与所有心血管代谢危险因素之间具有较高的相关性。VAT 与 MS 之间的最高调整比值比（每 SD）是男性 L2-L3 图像（OR 4.53）和女性 L1-L2 图像（OR 4.87），高于 L4-L5 图像（OR 3.22 男性，OR 4.71 女性）。然而，女性 L1-L2 VAT（OR 4.87）和 L4-L5（OR 4.71）之间的 OR 差异不大。
本研究结果表明，无论测量部位如何，VAT 与 MS 的相关性均强于 ASAT，在上腹部（L2-L3 或 L3-L4）的图像可能是韩国男性 VAT 与 MS 之间关系的更好预测指标。
