Department of Ophthalmology, Eye Clinic, St James's University Hospital, Leeds, UK.
Eye (Lond). 2010 Jun;24(6):994-8. doi: 10.1038/eye.2009.271. Epub 2009 Nov 13.
In a retrospective review, the functional effects of intra-vitreal ranibizumab monotherapy in patients with sub-foveal haemorrhage secondary to choroidal neovascularisation (CNV) in age-related macular degeneration (ARMD) are reported.
Twelve eyes of 12 patients were treated with intra-vitreal ranibizumab (0.5 mg in 0.05 ml) in accordance with current practice. Follow-up was arranged at monthly intervals. Eleven patients completed 6 months and seven completed 12 months of follow-up. Duration of haemorrhage, lesion size, ETDRS letter score at baseline, and follow-up were analysed.
The mean time for complete clearance of sub-retinal haemorrhage was 4.7 months (range 3-7 months). After 6 months, visual acuity was stable or improved in 7 of 11 eyes and the mean change in ETDRS letter score was +7.6 letters (P>0.05). After 12 months, visual acuity was stable or improved in five of seven eyes and the mean change in ETDRS letter score was +7.3 letters (P>0.05). For the seven cases with 12 months of follow-up, a mean of six injections were given. Two patients had a decrease in acuity of >15 ETDRS letters during follow-up. No other local or systemic side-effects were reported.
Intra-vitreal ranibizumab monotherapy may be an effective treatment for sub-foveal haemorrhage secondary to CNV in ARMD.
本回顾性研究报告了玻璃体内雷珠单抗单药治疗年龄相关性黄斑变性（AMD）脉络膜新生血管（CNV）性黄斑下出血的功能效果。
根据当前的实践，12 名患者（12 只眼）接受玻璃体内雷珠单抗（0.5mg/0.05ml）治疗。安排每月随访。11 名患者完成了 6 个月的随访，7 名患者完成了 12 个月的随访。分析出血持续时间、病变大小、基线时 ETDRS 字母评分以及随访情况。
视网膜下出血完全清除的平均时间为 4.7 个月（3-7 个月）。6 个月后，11 只眼中有 7 只视力稳定或提高，平均 ETDRS 字母评分提高了+7.6 个字母（P>0.05）。12 个月后，7 只眼中有 5 只视力稳定或提高，平均 ETDRS 字母评分提高了+7.3 个字母（P>0.05）。在 7 例有 12 个月随访的病例中，平均给予 6 次注射。2 例患者在随访期间视力下降超过 15 个 ETDRS 字母。未报告其他局部或全身不良反应。
玻璃体内雷珠单抗单药治疗可能是 AMD 脉络膜新生血管性黄斑下出血的有效治疗方法。
