茶碱相关性婴儿癫痫持续状态：药代动力学与栓剂使用风险。
Theophylline-associated status epilepticus in an infant: pharmacokinetics and the risk of suppository use.
机构信息
Department of Pediatrics, Graduate School of Medicine, Gifu University, Yanagido 1-1, Gifu, 501-1194, Japan.
出版信息
World J Pediatr. 2009 Nov;5(4):316-8. doi: 10.1007/s12519-009-0061-y. Epub 2009 Nov 13.
BACKGROUND
Theophylline has been widely used to treat asthma, but recent studies have revealed that the possible risks for seizure may result in the revision of the therapeutic guidelines.
METHODS
An 8-month-old boy who had been treated with oral sustained-release theophylline and additional aminophylline suppository was hospitalized. A combination of diazepam, lidocaine and thiopental was required to stop his convulsion.
RESULTS
The pharmacokinetic study indicated that the usage of a sustained-release formula should not usually be over 15 mg/ml, but the additional use of an aminophylline suppository elevated the concentration to over 20 mg/ml and resulted in the severe adverse effects.
CONCLUSION
The parents of children and also physicians should be educated to ensure the proper use of the suppository formula.
背景
茶碱被广泛用于治疗哮喘，但最近的研究表明，茶碱可能引发癫痫的风险，这可能导致治疗指南的修订。
方法
一名 8 个月大的男孩一直在服用口服缓释茶碱和额外的氨茶碱栓剂，他因抽搐住院。需要使用地西泮、利多卡因和硫喷妥钠来控制他的抽搐。
结果
药代动力学研究表明，通常不应将缓释配方的使用超过 15mg/ml，但额外使用氨茶碱栓剂会将浓度提高到超过 20mg/ml，导致严重的不良反应。
结论
应教育儿童的家长和医生确保栓剂配方的正确使用。
Zotero 插件