Mosbech H, Paulsen H, Søborg M
Pharmatherapeutica. 1984;3(9):626-30.
In a short-term study, a new sustained-release preparation of proxyphylline (2400 mg/day) was compared to theophylline (800 mg/day) and placebo. A double-blind crossover design was used, and 10 adult asthmatics participated. No significant differences were found between the treatments with regard to relief of asthma symptoms, need for additional medication or incidence and intensity of side-effects. In the placebo period, morning peak-flow was significantly lower compared to active treatment periods.
在一项短期研究中，将新的丙羟茶碱缓释制剂（2400毫克/天）与茶碱（800毫克/天）及安慰剂进行了比较。采用双盲交叉设计，10名成年哮喘患者参与。在缓解哮喘症状、额外用药需求或副作用的发生率及严重程度方面，各治疗组之间未发现显著差异。在安慰剂阶段，与积极治疗阶段相比，晨间峰值呼气流速显著降低。
