Clinical Psychopharmacology Unit, University College London, Gower Street, London, UK.
Psychopharmacology (Berl). 2010 Jan;208(1):67-74. doi: 10.1007/s00213-009-1709-y. Epub 2009 Nov 13.
Acute alcohol intoxication induces a selective impairment of recognition memory associated with conscious recollection whilst recognition based on familiarity is left intact.
We aimed to further elucidate the acute effects of alcohol on recognition memory by assessing three different doses of alcohol and examining the way in which this affected the recollection and familiarity components of recognition memory in comparison to a placebo group.
A double-blind independent design was used, and participants received either alcohol (0.4, 0.6 or 0.8 g/kg) or a placebo drink. Participants encoded word pairs with depth of processing manipulated under generate and read conditions. Recognition memory was assessed and recollective awareness was examined through use of the remember-know procedure.
Alcohol produced a dose-dependent reduction in recognition memory associated with recollection, evidenced by decreases in the number of correctly recognised items with 'remember' responses compared to placebo. Recognition based on a familiarity, evidenced by 'know' responses, showed no differences between groups or pattern of reduction compared to the placebo group. However, a negative correlation was found between recognition based on familiarity and levels of intoxication.
Alcohol-induced impairments in recognition memory occur in a dose-dependent manner, specifically driven by reductions in recognition associated with conscious awareness.
急性酒精中毒会导致与有意识回忆相关的识别记忆选择性损伤，而基于熟悉度的识别记忆则不受影响。
通过评估三种不同剂量的酒精，进一步阐明酒精对识别记忆的急性影响，并研究这种影响与安慰剂组相比如何影响识别记忆的回忆和熟悉度成分。
采用双盲独立设计，参与者接受酒精（0.4、0.6 或 0.8 g/kg）或安慰剂饮料。参与者在生成和阅读条件下进行深度处理的单词对编码。通过使用“记得-知道”程序评估识别记忆，并检查回忆意识。
酒精导致与回忆相关的识别记忆呈剂量依赖性下降，表现为与安慰剂相比，“记得”反应正确识别的项目数量减少。基于熟悉度的识别，表现为“知道”反应，与组间或与安慰剂组相比没有差异或减少模式。然而，发现基于熟悉度的识别与中毒水平之间存在负相关。
酒精引起的识别记忆损伤呈剂量依赖性，特别是与有意识意识相关的识别损伤。
