Department of Otolaryngology, Tokyo Postal Services Agency Hospital, Tokyo, Japan.
Cephalalgia. 2009 Dec;29(12):1259-66. doi: 10.1111/j.1468-2982.2009.01860.x.
To clarify if migraine-associated vertigo (MAV) and Meniere's disease (MD) share a common pathophysiology, vestibular-evoked myogenic potentials (VEMP) were measured in 11 patients with MAV, 11 with unilateral MD and eight healthy subjects. As acoustic stimuli, tone bursts (TB; 250, 500, 1000 and 2000 Hz) were presented. In healthy subjects, 500-Hz TB evoked the largest amplitude. To quantify this tendency, 500-1000 VEMP slope was calculated, and 500-1000 VEMP slope was the smallest on the affected side of MD patients. Among the 11 MD patients, five had significantly decreased 500-1000 VEMP asymmetry (shift of the tuning to 1000 Hz). Three of the 11 MAV patients also showed a significantly decreased 500-1000 VEMP slope. This finding suggests that MAV might share a common pathophysiology with MD. In addition to this finding, four of the other eight MAV patients showed prolonged p13 latencies. This suggests that MAV could consist of patients with different lesion sites.
为了阐明偏头痛相关性眩晕（MAV）和梅尼埃病（MD）是否具有共同的病理生理学基础，我们测量了 11 例 MAV 患者、11 例单侧 MD 患者和 8 名健康对照者的前庭诱发肌源性电位（VEMP）。我们使用纯音刺激（250、500、1000 和 2000 Hz 的短音爆发）作为声学刺激。在健康对照组中，500 Hz 的短音爆发诱发的振幅最大。为了量化这种趋势，我们计算了 500-1000 Hz 的 VEMP 斜率，发现 MD 患者患侧的 500-1000 Hz 的 VEMP 斜率最小。在 11 例 MD 患者中，有 5 例患者的 500-1000 Hz 的 VEMP 不对称性（向 1000 Hz 调谐的偏移）显著降低。11 例 MAV 患者中有 3 例也表现出显著降低的 500-1000 Hz 的 VEMP 斜率。这一发现表明 MAV 可能与 MD 具有共同的病理生理学基础。除了这一发现，其他 8 例 MAV 患者中有 4 例患者的 p13 潜伏期延长。这表明 MAV 可能包括不同病变部位的患者。
