Department of Ophthalmology, University of Crete, Heraklion, Greece.
Photochem Photobiol. 2010 Jan-Feb;86(1):194-9. doi: 10.1111/j.1751-1097.2009.00638.x. Epub 2009 Nov 12.
We studied the effect on the intraocular pressure (IOP) and the ciliary body (CB) morphology after four consecutive contact transcleral photodynamic treatments of the ciliary body (CB-PDT) with verteporfin in pigmented rabbits. Twenty-two pigmented rabbits underwent CB-PDT (study group), performed once (six rabbits) or repeated for up to four times (16 rabbits). Six additional rabbits received only laser treatment without photosensitizer administration (control group). CB-PDT was performed in one eye in rabbits of the study group, with the fellow eye serving as internal control. Verteporfin dosage was 1 mg kg(-1) as bolus injection and laser settings were 40 mW (600 microm core optical fiber) for 1.5 min per spot, for 10 spots. In repeated CB-PDT, treatments were performed in 4-day intervals. Daily IOP measurements were recorded. Histological studies were performed at selected time points. An IOP reduction, more sustained following repeated treatments, was detected in all treated eyes but not in fellow eyes or in the control group. On the average, the IOP was restored to pretreatment levels 4 days after the last treatment. No serious adverse events were observed and the CB architecture was intact at the end of the experiment. Repeated CB-PDT is safe and results in a short-term reduction of IOP. Induced CB alterations are reversible.
我们研究了连续四次接触性巩膜光动力疗法（CB-PDT）对兔眼内压（IOP）和睫状体（CB）形态的影响。22 只色素兔接受了 CB-PDT（研究组），其中 6 只接受了一次治疗（6 只兔子），16 只接受了最多 4 次重复治疗。另外 6 只兔子仅接受激光治疗而不给予光敏剂（对照组）。在研究组的兔子中，一只眼接受 CB-PDT，对侧眼作为内部对照。兔静脉注射 1mg/kg 卟啉衍生物（verteporfin），激光设置为 40mW（600μm 光纤芯），每个光斑照射 1.5 分钟，共 10 个光斑。在重复 CB-PDT 中，治疗间隔为 4 天。每天记录 IOP 测量值。在选定的时间点进行组织学研究。所有治疗眼均检测到 IOP 降低，且重复治疗后 IOP 降低更持久，但对侧眼或对照组则没有。平均而言，最后一次治疗后 4 天 IOP 恢复到治疗前水平。未观察到严重不良事件，实验结束时 CB 结构完整。重复 CB-PDT 是安全的，并导致短期眼压降低。诱导的 CB 改变是可逆的。
