Whitmore W F, Warner J A, Thompson I M
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
Cancer. 1991 Feb 15;67(4):1091-6. doi: 10.1002/1097-0142(19910215)67:4<1091::aid-cncr2820670437>3.0.co;2-j.
Seventy-five patients with clinical Stage B histologically proven prostatic cancer accumulated over a 40-year period and receiving no therapy for at least 1 year after histologic diagnosis were retrospectively reviewed. Twenty-nine patients had Stage B1 lesions, 37 had B2, and nine had B3 lesions; median follow-up for these patients was 124, 120, and 96 months, respectively. Five ultimately received pelvic lymph node dissection with iodine-125 implantation, 23 had transurethral resection of the prostate, and 18 had endocrine therapy. Of those tumors which progressed, 18 of 19 (95%) B1, 26 of 29 (90%) B2, and four of four (100%) B3 lesions demonstrated local progression first. Six of 29 (21%) B1, 17 of 37 (46%) B2, and two of nine (22%) B3 tumors developed recognized distant metastasis. Actuarial survival at 15 years was 67%, 39%, and 63% for patients with B1, B2, and B3 lesions, respectively. These data indicate the varied and potentially protracted course of patients with clinical Stage B prostatic cancer.
回顾性分析了40年间积累的75例经组织学证实为临床B期前列腺癌患者，这些患者在组织学诊断后至少1年未接受治疗。29例患者为B1期病变，37例为B2期，9例为B3期病变；这些患者的中位随访时间分别为124、120和96个月。5例最终接受了盆腔淋巴结清扫并植入碘-125，23例行经尿道前列腺切除术，18例接受内分泌治疗。在进展的肿瘤中，19例B1期病变中的18例（95%）、29例B2期病变中的26例（90%）和4例B3期病变中的4例（100%）首先表现为局部进展。29例B1期肿瘤中的6例（21%）、37例B2期肿瘤中的17例（46%）和9例B3期肿瘤中的2例（22%）发生了远处转移。B1、B2和B3期病变患者15年的精算生存率分别为67%、39%和63%。这些数据表明临床B期前列腺癌患者的病程多样且可能迁延。
