Animal Physiology Laboratory, Life Sciences Department, UR/08-73 Sfax Faculty of Sciences, BP 1171, 3000 Sfax, Tunisia.
Ecotoxicol Environ Saf. 2010 May;73(4):671-8. doi: 10.1016/j.ecoenv.2009.10.002. Epub 2009 Nov 12.
Chromium is a toxic metal implicated in human diseases. This study was focused on investigating the possible protective effect of Se against K(2)Cr(2)O(7). Female Wistar rats, used in this study, were divided into four groups of six animals each: group I served as control which received standard diet; group II received orally only K(2)Cr(2)O(7) (700 ppm equivalent to 67 mg/kgbw); group III received both K(2)Cr(2)O(7) and Se (0.5 mg/kg of diet); group IV received Se (0.5mg Na(2)SeO(3)/kg of diet). The exposure of rats to K(2)Cr(2)O(7) for 21 days provoked renal damages with a significant increase in kidney malondialdehyde, superoxide dismutase, plasma creatinine, and uric acid levels, while catalase, glutathione peroxidase, non-protein thiol, Metallothionein and plasma urea levels decreased. Coadministration of Se in the diet of chromium-treated group improved malondialdehyde, renal biomarkers levels and antioxidant enzyme activities. Kidney histological studies confirmed biochemical parameters and the beneficial role of selenium.
铬是一种有毒金属，与人类疾病有关。本研究旨在研究硒对 K(2)Cr(2)O(7)的可能保护作用。本研究中使用的雌性 Wistar 大鼠被分为四组，每组六只动物：第 I 组作为对照，给予标准饮食；第 II 组仅口服 K(2)Cr(2)O(7)（相当于 67mg/kgbw 的 700ppm）；第 III 组给予 K(2)Cr(2)O(7)和 Se（饮食中 0.5mg/kg）；第 IV 组给予 Se（饮食中 0.5mg Na(2)SeO(3)/kg）。大鼠暴露于 K(2)Cr(2)O(7) 21 天会引起肾脏损伤，导致肾脏丙二醛、超氧化物歧化酶、血浆肌酐和尿酸水平显著升高，而过氧化氢酶、谷胱甘肽过氧化物酶、非蛋白巯基、金属硫蛋白和血浆尿素水平降低。饮食中同时给予 Se 可改善铬处理组的丙二醛、肾生物标志物水平和抗氧化酶活性。肾脏组织学研究证实了硒的生化参数和有益作用。
