Department of Radiation Oncology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
Clin Plast Surg. 2010 Jan;37(1):147-60. doi: 10.1016/j.cps.2009.07.007.
Cutaneous melanoma is a disease that often has an aggressive and unpredictable course. It was historically thought to be a radioresistant neoplasm; however, substantial radiobiologic and clinical evidence has emerged to refute this notion. Improved local control has been demonstrated with the use of adjuvant radiation therapy delivered to the primary site or regional lymphatics in patients with high-risk clinical or pathologic features. Despite improved local control, high-risk cutaneous melanoma often spreads systemically, leading to poor survival. In the setting of systemic progression, radiation therapy can frequently palliate symptomatic sites of metastatic disease.
皮肤黑色素瘤是一种具有侵袭性和不可预测病程的疾病。过去人们认为它对放疗有抗性，但大量的放射生物学和临床证据反驳了这一观点。对于具有高危临床或病理特征的患者，在原发部位或区域淋巴结给予辅助放疗，已证实可改善局部控制。尽管局部控制得到改善，但高危皮肤黑色素瘤常发生全身转移，导致预后不良。在全身进展的情况下，放射治疗通常可以缓解转移性疾病的症状部位。
