State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, China.
Colloids Surf B Biointerfaces. 2010 Mar 1;76(1):123-7. doi: 10.1016/j.colsurfb.2009.10.024. Epub 2009 Oct 23.
Titanium oxide (TiO(2)) films were successfully deposited onto the polymer substrates of polytetrafluoroethylene (PTFE), polyethylene (PE), and polyethylene terephthalate (PET), which were pre-modified with polydopamine coating (polydopamine and its coating are coded as PDA and PDAc, respectively), by a simple liquid phase deposition (LPD) process. The morphology and chemical state of the obtained TiO(2) films were characterized by field emission scanning electron microscope (FE-SEM) and X-ray photoelectron spectroscopy (XPS), respectively. Subsequently, the biocompatibility of the samples was investigated by 3-(4,5-dimethyldiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) colorimetric assay and acridine orange staining of MC-3T3 osteoblast cells, and the results demonstrated that the fabricated TiO(2) films could markedly improve the in vitro cytocompatibility. So, the presented route is anticipated to be a promising surface modification methodology to improve the practical outcome of the implanted materials for its versatility and validity.
钛氧化物（TiO(2)）薄膜通过简单的液相沉积（LPD）工艺成功沉积在经过聚多巴胺涂层（聚多巴胺及其涂层分别编码为 PDA 和 PDAc）预处理的聚合物基底上，如聚四氟乙烯（PTFE）、聚乙烯（PE）和聚对苯二甲酸乙二醇酯（PET）。通过场发射扫描电子显微镜（FE-SEM）和 X 射线光电子能谱（XPS）分别对获得的 TiO(2)薄膜的形貌和化学状态进行了表征。随后，通过 3-(4,5-二甲基噻唑-2-基)-2,5-二苯基四氮唑溴盐（MTT）比色法和吖啶橙染色 MC-3T3 成骨细胞来研究样品的生物相容性，结果表明所制备的 TiO(2)薄膜可以显著提高体外细胞相容性。因此，该方法有望成为一种有前途的表面改性方法，以提高植入材料的实际效果，因为其具有多功能性和有效性。
