University of Utah School of Medicine, Department of Pediatrics, Division of Pediatric Infectious Diseases, PO Box 581289, Salt Lake City, UT, USA.
Pediatr Infect Dis J. 2010 Jan;29(1):6-9. doi: 10.1097/INF.0b013e3181b4b950.
We evaluated the presentation, outcomes, and the risk of serious bacterial infection (SBI) in infants <3 months old with influenza virus infection.
We identified demographic, hospitalization, and microbiologic data from computerized medical records for all infants and children <24 months of age, with laboratory confirmed influenza infection cared for at a tertiary care children's hospital during 4 winter seasons (2004-2008). We compared those <3 months of age with older groups.
We identified 833 children <24 months of age with laboratory-confirmed influenza. Of those, 218 were <3 months old. Influenza accounted for 3.6% of all evaluations of febrile infants and 12% of febrile infant encounters during winter. Infants <3 months of age were less likely to have a high risk chronic medical condition, but were more likely to be hospitalized than children 3 to <24 months old (P < 0.005). Infants <3 months with influenza had fewer prolonged hospital stays than those 3 to <6 months old [P = 0.056; OR: 0.5 (0.24-1.0)] and 6 to <12 months old [P = 0.011; OR: 0.43 (0.24-0.83)]. Five (2.3%) infants <3 months old had SBI.
Infants <3 months of age with influenza virus infection often present with fever alone. Although they are more likely to be hospitalized than those 3 to <24 months old, hospital stays are short and outcomes generally good. Infants with influenza virus infection have a low risk of concomitant SBI.
我们评估了 <3 个月大的流感病毒感染婴儿的表现、结局以及严重细菌感染(SBI)的风险。
我们从一家三级儿童医院的计算机病历中确定了所有 <24 个月大的婴儿和儿童的人口统计学、住院和微生物学数据,这些儿童患有经实验室确认的流感感染,并在 4 个冬季(2004-2008 年)期间接受治疗。我们将 <3 个月大的婴儿与年龄较大的组进行了比较。
我们共确定了 833 名 <24 个月大的实验室确诊流感患儿,其中 218 名 <3 个月大。流感占所有发热婴儿评估的 3.6%,也是发热婴儿冬季就诊的 12%。 <3 个月大的婴儿患高风险慢性疾病的可能性较小,但住院的可能性大于 3 至 <24 个月大的婴儿(P < 0.005)。与 3 至 <6 个月大的婴儿相比(P = 0.056;OR:0.5 [0.24-1.0])和 6 至 <12 个月大的婴儿相比(P = 0.011;OR:0.43 [0.24-0.83]), <3 个月大的流感婴儿住院时间更短。5 名(2.3%)<3 个月大的婴儿发生严重细菌感染。
<3 个月大的流感病毒感染婴儿常以发热为唯一表现。虽然与 3 至 <24 个月大的婴儿相比,他们更有可能住院,但住院时间较短,结局通常较好。流感病毒感染的婴儿并发严重细菌感染的风险较低。