Kramarova L I, Ziganshin R Kh, Gakhova E N
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Bioorg Khim. 2009 Sep-Oct;35(5):597-609. doi: 10.1134/s1068162009050021.
Hibernation is a natural model of Tolerance of hypometabolism, hypothermia, hypoxia, bradycardia, and longterm hypophagia. Here, we review recent advances in the isolation and identification of some natural endogenous regulators from hibernating and cold-adapted animals: proteins, peptides, and nonpeptide substances. We also discuss the employment of molecular, biochemical, and physiological bases of natural hypobiosis in ecology, cryomedicine, and the cryopreservation of genetic material from rare and endangered species. We suppose that our approaches can be extensively used (i) in medicine, when there is a need to slow down or suspend life processes for a short time; (ii) for the adaptation of humans to cold; and (iii) in long-term space flights.
冬眠是低代谢、体温过低、缺氧、心动过缓和长期少食耐受的自然模式。在此，我们综述了从冬眠和冷适应动物中分离和鉴定一些天然内源性调节剂（蛋白质、肽和非肽物质）的最新进展。我们还讨论了自然低生物活性在生态学、低温医学以及珍稀濒危物种遗传物质冷冻保存中的分子、生化和生理基础的应用。我们认为，我们的方法可广泛用于：（i）医学领域，即在需要短时间减缓或暂停生命过程时；（ii）用于人类适应寒冷；以及（iii）在长期太空飞行中。
