Fourie Carla Maria T, Van Rooyen Johannes M, Kruger Annamarie, Schutte Aletta E
HART (Hypertension in Africa Research Team), Subject Group Physiology, North-West University, Potchefstroom, South Africa.
Lipids. 2010 Jan;45(1):73-80. doi: 10.1007/s11745-009-3369-4. Epub 2009 Nov 15.
Dyslipidemia has been documented worldwide among human immunodeficiency virus-infected (HIV) individuals and these changes are reminiscent of the metabolic syndrome (MetS). In South Africa, with the highest number of HIV infections worldwide, HIV-1 subtype C is prevalent, while HIV-1 subtype B (genetically different from C) prevails in Europe and the United States. We aimed to evaluate if HIV infection (subtype C) is associated with dyslipidemia, inflammation and the occurrence of the MetS in Africans. Three hundred newly diagnosed HIV-infected participants were compared to 300 age, gender, body mass index and locality matched uninfected controls. MetS was defined according to the Adult Treatment Panel III (ATP III) and International Diabetes Federation (IDF) criteria. The HIV-infected group showed lower high density lipoprotein cholesterol (1.23 vs. 1.70 mmol/L) and low density lipoprotein cholesterol (2.60 vs. 2.80 mmol/L) and higher triglycerides (1.29 vs. 1.15 mmol/L), C-reactive protein (3.31 vs. 2.13 mg/L) and interleukin 6 (4.70 vs. 3.72 pg/L) levels compared to the uninfected group. No difference in the prevalence of the MetS was seen between the two groups (ATP III, 15.2 vs. 11.5%; IDF, 21.1 vs. 22.6%). This study shows that HIV-1 subtype C is associated with dyslipidemia, but not with a higher incidence of MetS in never antiretroviral-treated HIV-infected Africans.
血脂异常在全球范围内的人类免疫缺陷病毒（HIV）感染者中都有记录，这些变化让人联想到代谢综合征（MetS）。在全球HIV感染人数最多的南非，HIV-1 C亚型流行，而HIV-1 B亚型（与C亚型在基因上不同）在欧洲和美国占主导地位。我们旨在评估HIV感染（C亚型）是否与非洲人的血脂异常、炎症和代谢综合征的发生有关。将300名新诊断的HIV感染者与300名年龄、性别、体重指数和居住地点相匹配的未感染者进行比较。根据成人治疗小组III（ATP III）和国际糖尿病联合会（IDF）的标准定义代谢综合征。与未感染组相比，HIV感染组的高密度脂蛋白胆固醇水平较低（1.23 vs. 1.70 mmol/L）、低密度脂蛋白胆固醇水平较低（2.60 vs. 2.80 mmol/L），甘油三酯（1.29 vs. 1.15 mmol/L）、C反应蛋白（3.31 vs. 2.13 mg/L）和白细胞介素6（4.70 vs. 3.72 pg/L）水平较高。两组之间代谢综合征的患病率没有差异（ATP III标准下，分别为15.2%和11.5%；IDF标准下，分别为21.1%和22.6%）。这项研究表明，在从未接受过抗逆转录病毒治疗的HIV感染非洲人中，HIV-1 C亚型与血脂异常有关，但与代谢综合征的较高发病率无关。
