Gold Michael H, Heath Amanda D, Biron Julie A
Tennessee Clinical Research Center, Nashville, TN 37215, USA.
J Drugs Dermatol. 2009 Nov;8(11 Suppl):s4-8.
Fractional photothermolysis with a CO2 laser shows promise in the treatment of photodamaged skin. The purpose of this study was to evaluate a fractional CO2 laser device (SmartSkin, Cynosure, Westford, MA) for the treatment of facial photodamage.
Twelve subjects seeking treatment of facial hyperpigmentation, skin laxity, wrinkles and fine lines, enlarged pores and acne scars enrolled in the study. Each subject was treated twice with the SmartSkin device at three- to five-week intervals. Results were evaluated at one week, one month and three months after the final treatment.
All 12 subjects completed the study. Physician and subject assessments both indicated that clinical improvements in all photodamage parameters were apparent at one month and persisted at least three months. Improvements in acne scars were noted but not graded. Eleven subjects would recommend the treatment to family and friends. The median pain scores during the initial and final treatments were 2.00 and 2.00, respectively, on a scale of 0-5. Only one adverse effect, facial edema, was judged "probably related to treatment."
The SmartSkin fractional laser device improves photodamaged skin for at least three months. The treatment was well tolerated and adverse effects were limited to transient facial edema.
二氧化碳激光分次光热解在治疗光损伤皮肤方面显示出前景。本研究的目的是评估一种分次二氧化碳激光设备（SmartSkin，赛诺秀公司，马萨诸塞州韦斯特福德）用于治疗面部光损伤。
12名寻求治疗面部色素沉着、皮肤松弛、皱纹和细纹、毛孔粗大及痤疮瘢痕的受试者纳入本研究。每位受试者使用SmartSkin设备进行两次治疗，间隔三至五周。在最后一次治疗后的一周、一个月和三个月对结果进行评估。
所有12名受试者完成了研究。医生和受试者的评估均表明，所有光损伤参数的临床改善在一个月时明显，并至少持续三个月。痤疮瘢痕有改善但未分级。11名受试者会向家人和朋友推荐该治疗。初始治疗和最后治疗期间的疼痛评分中位数分别为2.00（0 - 5分制）。仅一种不良反应，即面部水肿，被判定“可能与治疗有关”。
SmartSkin分次激光设备改善光损伤皮肤至少三个月。该治疗耐受性良好，不良反应仅限于短暂的面部水肿。
