Vestergaard Peter, Rejnmark Lars, Mosekilde Leif
Department of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus, Denmark.
Acta Orthop. 2009 Oct;80(5):525-30. doi: 10.3109/17453670903316835.
Patients with a hip fracture have a high mortality; however, it is not clear how large the loss of life-years is over an extended observation period.
This was a cohort study involving all patients in Denmark who suffered a hip fracture between 1977 and 2001 (n = 169,145). The survival rate for these patients was compared to that for age- and sex-matched subjects without a hip fracture (n = 524,010).
There was a substantial degree of excess mortality, with a pronounced variation in age and sex. The absolute number of life-years lost compared to age-matched subjects without a hip fracture was larger in younger subjects than in older subjects (men aged 51-60 years lived 7.5 years less on average while men over 80 years of age lived 3 years less). Expressed as a percentage, however, older subjects had the largest relative loss of expected remaining years of life. Men < or = 50 years of age lost 18% of their expected remaining years of life, as opposed to men > 80 years of age who lost as much as 58% of their expected remaining years of life. In women, the trend was similar but less pronounced (27% loss in women < or = 50 years of age vs. 38% in women > 80 years of age).
A large proportion of the estimated remaining life is lost after a hip fracture, even in younger patients. Prevention may save life years, although not all of the years lost after a hip fracture may be due to the hip fracture per se.
髋部骨折患者死亡率较高;然而,在较长观察期内生命年损失究竟有多大尚不清楚。
这是一项队列研究,纳入了1977年至2001年间丹麦所有髋部骨折患者(n = 169,145)。将这些患者的生存率与年龄和性别匹配的无髋部骨折受试者(n = 524,010)的生存率进行比较。
存在相当程度的超额死亡率,在年龄和性别上有显著差异。与年龄匹配的无髋部骨折受试者相比,生命年的绝对损失数量在年轻受试者中比在老年受试者中更大(51 - 60岁男性平均少活7.5年,而80岁以上男性少活3年)。然而,以百分比表示,老年受试者预期剩余生命年的相对损失最大。50岁及以下男性损失了其预期剩余生命年的18%,而80岁以上男性损失了高达其预期剩余生命年的58%。在女性中,趋势相似但不那么明显(50岁及以下女性损失27%,而80岁以上女性损失38%)。
即使在年轻患者中,髋部骨折后估计的剩余生命也有很大一部分损失。预防可能挽救生命年,尽管髋部骨折后损失的并非所有年份都可能直接归因于髋部骨折本身。