Bottle Alex, Aylin Paul
Dr Foster Unit at Imperial College London, Department of Primary Care and Social Medicine, Imperial College London, London W6 8RP.
BMJ. 2006 Apr 22;332(7547):947-51. doi: 10.1136/bmj.38790.468519.55. Epub 2006 Mar 22.
To estimate the number of deaths and readmissions associated with delay in operation after femoral fracture.
Analysis of inpatient hospital episode statistics.
NHS hospital trusts in England with at least 100 admissions for fractured neck of femur during the study period. Patients People aged > or = 65 admitted from home with fractured neck of femur and discharged between April 2001 and March 2004.
In hospital mortality and emergency readmission within 28 days.
There were 129,522 admissions for fractured neck of femur in 151 trusts with 18,508 deaths in hospital (14.3%). Delay in operation was associated with an increased risk of death in hospital, which was reduced but persisted after adjustment for comorbidity. For all deaths in hospital, the odds ratio for more than one day's delay relative to one day or less was 1.27 (95% confidence interval 1.23 to 1.32) after adjustment for comorbidity. The proportion with more than two days' delay ranged from 1.1% to 62.4% between trusts. If death rates in patients with at most one day's delay had been repeated throughout all 151 trusts in this study, there would have been an average of 581 (478 to 683) fewer total deaths per year (9.4% of the total). There was little evidence of an association between delay and emergency readmission.
Delay in operation is associated with an increased risk of death but not readmission after a fractured neck of femur, even with adjustment for comorbidity, and there is wide variation between trusts.
评估股骨骨折后手术延迟所导致的死亡人数及再入院情况。
对住院患者病历统计数据进行分析。
在研究期间,英格兰国民健康服务体系(NHS)下属的医院信托机构中,至少有100例股骨颈骨折患者入院治疗。研究对象为年龄≥65岁、因股骨颈骨折从家中入院并于2001年4月至2004年3月期间出院的患者。
住院死亡率及28天内的急诊再入院情况。
151家信托机构中有129,522例股骨颈骨折患者入院,其中18,508例患者在医院死亡(14.3%)。手术延迟与住院死亡风险增加相关,在对合并症进行调整后,死亡风险虽有所降低但仍然存在。对于所有住院死亡患者,在对合并症进行调整后,手术延迟超过1天相对于延迟1天及以内的比值比为1.27(95%置信区间为1.23至1.32)。各信托机构中手术延迟超过2天的患者比例在1.1%至62.4%之间。如果将本研究中151家信托机构里手术延迟最多1天的患者死亡率推广至所有患者,那么每年平均死亡总数将减少581例(478至683例)(占死亡总数的9.4%)。几乎没有证据表明延迟与急诊再入院之间存在关联。
股骨颈骨折后,手术延迟与死亡风险增加相关,但与再入院无关,即便对合并症进行调整后依然如此,而且各信托机构之间存在较大差异。