Kothari S S
Institute of Cardiology, New Civil Hospital, Ahmedabad, India.
Int J Cardiol. 1991 Jan;30(1):9-13. doi: 10.1016/0167-5273(91)90118-9.
A genetically determined error in the handling of catecholamines by the developing heart has been speculated to cause hypertrophic cardiomyopathy. A critical appraisal of the published literature reveals that there is little actual experimental or clinical evidence favouring the role of catecholamines in the pathogenesis of hypertrophic cardiomyopathy. Other factors seem to be more important. An abnormality of myocardial growth, either induced by excessive growth promoting substance, or a genetically determined abnormality in myocardial responses to normal growth factors during life (but not in the fetal handling of catecholamines) is likely to be responsible for hypertrophic cardiomyopathy.
据推测，发育中的心脏在儿茶酚胺处理方面的基因决定错误会导致肥厚型心肌病。对已发表文献的批判性评估表明，几乎没有实际的实验或临床证据支持儿茶酚胺在肥厚型心肌病发病机制中的作用。其他因素似乎更为重要。心肌生长异常，要么是由过度的生长促进物质诱导，要么是由生命过程中（而非胎儿期儿茶酚胺处理过程中）心肌对正常生长因子的基因决定异常所导致，这可能是肥厚型心肌病的病因。
