Institut d'Investigació Biomèdica de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.
Clin Transl Oncol. 2009 Nov;11(11):721-7. doi: 10.1007/s12094-009-0434-7.
Activation of oncogenes and inactivation of tumour suppressor genes are common events during breast cancer initiation and progression and often determine treatment responsiveness. Indeed, these events need to be recreated in in vitro systems and in mouse cancer models in order to unravel the molecular mechanisms involved in breast cancer initiation and metastasis and assess their possible impact on responses to anticancer drugs. Optical-based imaging models are used to investigate and to follow important tumour progression processes. Moreover, the development of novel anticancer strategies requires more sensitive and less invasive methods to detect and monitor in vivo drug responses in breast cancer models. This review highlights some of the current strategies for modelling breast cancer in vitro and in the mouse, in order to answer biological or translational questions about human breast malignancies.
在乳腺癌的发生和发展过程中，癌基因的激活和肿瘤抑制基因的失活是常见事件，通常决定着治疗反应性。事实上，为了揭示乳腺癌发生和转移涉及的分子机制，并评估它们对抗癌药物反应的可能影响，这些事件需要在体外系统和小鼠癌症模型中重现。基于光学的成像模型用于研究和跟踪重要的肿瘤进展过程。此外，新型抗癌策略的发展需要更敏感和微创的方法来检测和监测乳腺癌模型中的体内药物反应。本综述强调了一些目前在体外和小鼠中模拟乳腺癌的策略，以回答关于人类乳腺癌恶性肿瘤的生物学或转化问题。
