Department of Biology, University of Rochester, Rochester, New York 14627, USA.
Genetics. 2010 Feb;184(2):401-10. doi: 10.1534/genetics.109.111245. Epub 2009 Nov 16.
Many studies have demonstrated the rapid diversification of reproductive genes that function after mating but before fertilization. This process might lead to the evolution of postmating, prezygotic barriers between species. Here, I investigate the phenotypic and genetic basis of postmating, prezygotic isolation between two closely related species of Drosophila, Drosophila virilis and D. americana. I show that a strong barrier to interspecific fertilization results in a 99% reduction in progeny production. A genetic interaction among maternal and paternal alleles at only a few loci prevents the fertilization of D. virilis females by D. americana males. These loci are autosomal and isolation acts recessively; the fertilization incompatibility is caused by at least two loci in the maternal D. virilis parent in combination with at least three loci in the paternal D. americana parent. These findings, together with results from classical experiments, suggest that male-female coevolution within D. americana may have driven postmating, prezygotic isolation between species.
许多研究表明，在交配后但在受精前起作用的生殖基因迅速多样化。这一过程可能导致物种间交配后、合子前障碍的进化。在这里，我研究了两个密切相关的果蝇物种——黑腹果蝇和美洲果蝇之间交配后、合子前隔离的表型和遗传基础。我表明，种间受精的一个强大障碍导致后代产量减少了 99%。仅少数几个位点的母本和父本等位基因之间的遗传相互作用阻止了黑腹果蝇雌性与美洲果蝇雄性的受精。这些位点是常染色体的，隔离是隐性的；受精不相容性至少是由母本黑腹果蝇亲本中的两个位点与父本美洲果蝇亲本中的至少三个位点共同引起的。这些发现，以及经典实验的结果，表明美洲果蝇内的雌雄共同进化可能导致了物种间的交配后、合子前隔离。
