Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvantia, USA.
Diabetes Care. 2010 Feb;33(2):341-3. doi: 10.2337/dc09-0713. Epub 2009 Nov 16.
While lower hemoglobin is generally associated with adverse events in diabetes, we have recently observed in type 1 diabetes that those with overt nephropathy had hemoglobin levels as high as 18.8 g/dl. We thus explored whether hemoglobin concentrations are generally higher in type 1 diabetes.
Baseline (1986-1988) hemoglobin levels from the Pittsburgh Epidemiology of Diabetes Complications Study (EDC) of type 1 diabetes were compared with general population data from the National Health and Nutrition Examination Survey (NHANES) III in the same age range as the EDC population (aged 8-48 years).
Both male and female EDC study participants had significantly higher hemoglobin levels than their NHANES III counterparts (men: 16.0 vs. 15.1 g/dl, P < 0.0001; women: 14.1 vs. 13.3 g/dl, P < 0.0001). The difference between the two populations was greatest in adolescent female subjects.
Hemoglobin levels may be higher in type 1 diabetes than in the general population, which may have important clinical implications.
虽然血红蛋白水平较低通常与糖尿病不良事件相关，但我们最近在 1 型糖尿病中观察到，有显性肾病的患者血红蛋白水平高达 18.8 g/dl。因此，我们探讨了 1 型糖尿病患者的血红蛋白浓度是否普遍较高。
比较了匹兹堡糖尿病并发症流行病学研究（EDC）中 1 型糖尿病患者的基线（1986-1988 年）血红蛋白水平与具有与 EDC 人群相同年龄范围（8-48 岁）的国家健康和营养检查调查（NHANES）III 的一般人群数据。
EDC 研究的男性和女性参与者的血红蛋白水平均明显高于 NHANES III 参与者（男性：16.0 与 15.1 g/dl，P < 0.0001；女性：14.1 与 13.3 g/dl，P < 0.0001）。两个群体之间的差异在青春期女性受试者中最大。
1 型糖尿病患者的血红蛋白水平可能高于一般人群，这可能具有重要的临床意义。
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