Tsurugizawa Tomokazu, Uematsu Akira, Uneyama Hisayuki, Torii Kunio
Institute of Life Sciences, Ajinomoto Co. Inc., Suzuki-cho 1-1, Kawasaki-ku, Kawasaki 210-8681, Japan.
Neuroreport. 2009 Dec 9;20(18):1625-9. doi: 10.1097/WNR.0b013e32833312e5.
The postingestive actions after intragastric or oronasal stimulation of fat have been well investigated. The blood oxygenation level-dependent (BOLD) signal changes, however, after intragastric load of corn oil emulsion have yet to be elucidated. Here, using functional magnetic resonance imaging, we investigated the BOLD signal response to gut corn oil emulsion in nonanesthetized rats. Intragastrically infused 7% corn oil emulsion induced a BOLD signal increase in several brain regions, including the bilateral amygdala, hippocampus and the ventral tegmental area. These results indicate that the limbic system responds to gut corn oil emulsion and that activation of this system could promote the reinforcing action for food with high fat content.
胃内或口鼻部给予脂肪刺激后的消化后行为已得到充分研究。然而，胃内注入玉米油乳剂后的血氧水平依赖（BOLD）信号变化尚未阐明。在此，我们使用功能磁共振成像技术，研究了未麻醉大鼠肠道内玉米油乳剂引起的BOLD信号反应。胃内注入7%玉米油乳剂可引起包括双侧杏仁核、海马体和腹侧被盖区在内的多个脑区的BOLD信号增加。这些结果表明，边缘系统对肠道内玉米油乳剂有反应，该系统的激活可能会促进对高脂肪食物的强化作用。
