Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Canada.
Int J Obes (Lond). 2010 Feb;34(2):340-7. doi: 10.1038/ijo.2009.229. Epub 2009 Nov 17.
To test the hypothesis that for any given body mass index (BMI) category, active individuals would have a smaller waist circumference than inactive individuals. Our second objective was to examine the respective contribution of waist circumference and physical inactivity on coronary heart disease (CHD) risk.
Prospective, population-based study with an 11.4-year follow-up.
A total of 21 729 men and women aged 45-79 years, residing in Norfolk, UK.
During follow-up, 2191 CHD events were recorded. Physical activity was evaluated using a validated lifestyle questionnaire that takes into account both leisure-time and work-related physical activity. Waist circumference was measured and BMI was calculated for each participant.
For both men and women, we observed that within each BMI category (<25.0, 25-30 and >or=30.0 kg m(-2)), active participants had a lower waist circumference than inactive participants (P<0.001). In contrast, within each waist circumference tertile, BMI did not change across physical activity categories (except for women with an elevated waist circumference). Compared with active men with a low waist circumference, inactive men with an elevated waist circumference had a hazard ratio (HR) for future CHD of 1.74 (95% confidence interval (CI), 1.34-2.27) after adjusting for age, smoking, alcohol intake and parental history of CHD. In the same model and after further adjusting for hormone replacement therapy use, compared with active women with a low waist circumference, inactive women with an elevated waist circumference had an HR for future CHD of 4.00 (95% CI, 2.04-7.86).
In any BMI category, inactive participants were characterized by an increased waist circumference, a marker of abdominal adiposity, compared with active individuals. Physical inactivity and abdominal obesity were both independently associated with an increased risk of future CHD.
验证以下假设，即对于任何给定的身体质量指数（BMI）类别，活跃个体的腰围都小于不活跃个体。我们的第二个目标是检查腰围和身体不活动对冠心病（CHD）风险的各自贡献。
前瞻性、基于人群的研究，随访时间为 11.4 年。
英国诺福克地区年龄在 45-79 岁的 21729 名男性和女性。
在随访期间，记录了 2191 例 CHD 事件。身体活动通过使用经过验证的生活方式问卷进行评估，该问卷考虑了休闲时间和与工作相关的身体活动。为每位参与者测量腰围并计算 BMI。
对于男性和女性，我们观察到，在每个 BMI 类别（<25.0、25-30 和>=30.0kg/m(2)）中，活跃参与者的腰围都小于不活跃参与者（P<0.001）。相比之下，在每个腰围三分位组中，BMI 并没有随着身体活动类别的变化而变化（除了腰围较高的女性）。与腰围较低且活跃的男性相比，腰围较高且不活跃的男性未来患 CHD 的风险比为 1.74（95%置信区间[CI]，1.34-2.27），调整了年龄、吸烟、饮酒和父母 CHD 病史等因素。在同一模型中，并且在进一步调整激素替代疗法使用后，与腰围较低且活跃的女性相比，腰围较高且不活跃的女性未来患 CHD 的风险比为 4.00（95%CI，2.04-7.86）。
在任何 BMI 类别中，与活跃个体相比，不活跃个体的腰围更大，这是腹部脂肪的标志。身体不活动和腹部肥胖均与未来 CHD 风险增加独立相关。
