Dai Mei, Zheng Xiuling, Xu Xu, Kong Xiangye, Li Xingyi, Guo Gang, Luo Feng, Zhao Xia, Wei Yu Quan, Qian Zhiyong
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China.
J Biomed Biotechnol. 2009;2009:595126. doi: 10.1155/2009/595126. Epub 2009 Nov 11.
A biodegradable sponge, composed of chitosan (CS) and sodium alginate (SA), was successfully obtained in this work. The sponge was ethereal and pliable. The chemical structure and morphology of the sponges was characterized by FTIR and SEM. The swelling ability, in vitro drug release and degradation behaviors, and an in vivo animal test were employed to confirm the applicability of this sponge as a wound dressing material. As the chitosan content in the sponge decreased, the swelling ability decreased. All types of the sponges exhibited biodegradable properties. The release of curcumin from the sponges could be controlled by the crosslinking degree. Curcumin could be released from the sponges in an extended period for up to 20 days. An in vivo animal test using SD rat showed that sponge had better effect than cotton gauze, and adding curcumin into the sponge enhanced the therapeutic healing effect.
在本研究中成功制备了一种由壳聚糖（CS）和海藻酸钠（SA）组成的可生物降解海绵。该海绵质地轻盈且柔韧。通过傅里叶变换红外光谱（FTIR）和扫描电子显微镜（SEM）对海绵的化学结构和形态进行了表征。采用溶胀能力、体外药物释放和降解行为以及体内动物试验来证实该海绵作为伤口敷料材料的适用性。随着海绵中壳聚糖含量的降低，溶胀能力下降。所有类型的海绵均表现出可生物降解的特性。姜黄素从海绵中的释放可通过交联度来控制。姜黄素可从海绵中持续释放长达20天。使用SD大鼠进行的体内动物试验表明，该海绵比棉纱布具有更好的效果，并且在海绵中添加姜黄素可增强治疗愈合效果。
