含藻酸盐/壳聚糖/马尾藻多糖的生物多功能海绵促进全层伤口愈合。
Bio-Multifunctional Sponges Containing Alginate/Chitosan/Sargassum Polysaccharides Promote the Healing of Full-Thickness Wounds.
机构信息
The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang 524023, China.
South Subtropical Crop Research Institute, China Academy of Tropical Agricultural Sciences, Zhanjiang 524023, China.
出版信息
Biomolecules. 2022 Oct 31;12(11):1601. doi: 10.3390/biom12111601.
Creation of bio-multifunctional wound dressings with potent hemostatic, antibacterial, anti-inflammatory, and angiogenesis features for bolstering the healing of full-thickness wounds is sought after for clinical applications. We created bio-multifunctional composite sponges by coupling alginate and chitosan with polysaccharides through electrostatic interactions, calcium ion (Ca) crosslinking, and lyophilization. Alginate/chitosan (AC) sponges with different concentrations of polysaccharides were obtained and termed AC, ACS-1%, ACS-2.5%, and ACS-5%. ACS-1% and ACS-2.5% sponges exhibited uniform porosity, high water vapor transmission rate, high water absorption, as well as good hemostatic and antibacterial abilities. ACS-2.5% sponges facilitated wound closure and promoted angiogenesis and re-epithelialization in the dermis. These data suggest that ACS sponges containing a certain amount of polysaccharides could be employed for treatment of full-thickness skin wounds.
为了临床应用，人们一直致力于开发具有强大止血、抗菌、抗炎和血管生成功能的生物多功能伤口敷料，以促进全层伤口的愈合。我们通过静电相互作用、钙离子（Ca）交联和冷冻干燥将海藻酸盐和壳聚糖与多糖结合起来，制备了生物多功能复合海绵。得到了具有不同多糖浓度的海藻酸盐/壳聚糖（AC）海绵，并分别命名为 AC、ACS-1%、ACS-2.5%和 ACS-5%。ACS-1%和 ACS-2.5%海绵具有均匀的孔隙率、高水蒸气透过率、高吸水性以及良好的止血和抗菌能力。ACS-2.5%海绵促进伤口闭合，并促进真皮中的血管生成和上皮再形成。这些数据表明，含有一定量多糖的 ACS 海绵可用于治疗全层皮肤伤口。
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