Sato Toshio, Yamadori Ichiro, Fujita Jiro, Hamada Noboru, Yonei Toshiro, Bandoh Shuji, Ohtsuki Yuji, Ishida Toshihiko
National Okayama Medical Center, Okayama.
Intern Med. 2004 Aug;43(8):721-6. doi: 10.2169/internalmedicine.43.721.
NSIP associated with primary lung cancer has been rarely reported. In the present report, three cases of histologically proven non-specific interstitial pneumonia (NSIP) associated with primary lung cancer are described. Importantly, in our 3 cases, interstitial pneumonia which is histologically proven to be NSIP was observed diffusely in both lungs. NSIP in these 3 cases responded to steroid therapy. However, 2 patients died from primary lung cancer and 1 patient died from progression of the interstitial pneumonia. Although the association between lung cancer and NSIP has been rarely documented, this combination was considered to be one of the paraneoplastic phenomena. The possible association between primary lung cancer and NSIP is discussed.
与原发性肺癌相关的非特异性间质性肺炎（NSIP）鲜有报道。在本报告中，描述了3例经组织学证实的与原发性肺癌相关的非特异性间质性肺炎病例。重要的是，在我们的3例病例中，经组织学证实为NSIP的间质性肺炎在双肺均有弥漫性观察到。这3例中的NSIP对类固醇治疗有反应。然而，2例患者死于原发性肺癌，1例患者死于间质性肺炎进展。尽管肺癌与NSIP之间的关联鲜有记录，但这种组合被认为是副肿瘤现象之一。本文讨论了原发性肺癌与NSIP之间可能的关联。
