School of Kinesiology, University of Michigan, 401 Washtenaw Avenue, Ann Arbor, Michigan 48109-2214, USA.
J Orthop Res. 2010 May;28(5):595-9. doi: 10.1002/jor.21038.
Quadriceps dysfunction, specifically weakness and central activation failure (CAF), has been implicated in the development and progression of knee osteoarthritis (OA), though few data are available to confirm its presence in early OA. The purpose of this study was to determine the presence and magnitude of quadriceps dysfunction in those with and without early knee OA. Thirty-five female volunteers were classified into two groups, OA (n=22) and control (n=13), based on the presence [Kellgren-Lawrence (K-L) grade 2] or absence (K-L grade 0-1) of mild OA, respectively. Isometric quadriceps strength and central activation ratio (CAR) were assessed and compared between groups utilizing a one-way ANOVA. Frequency statistics and Fisher's exact test were used to compare the percentage of women with and without CAF between groups. Quadriceps strength (control: 1.47+/-0.62 Nm/kg; OA: 1.30+/-0.62 Nm/kg; p=0.45) was not significantly different for women with and without mild OA. Further, the CAR (control: 0.91+/-0.07; OA: 0.87+/-0.12; p=0.19) did not differ between groups; however, women in both groups presented with CAF (control: 54%; OA: 73%; p=0.29). Our results suggest that the women with mild osteoarthritis do not present with quadriceps dysfunction.
股四头肌功能障碍，特别是肌力下降和中枢激活失败（CAF），与膝关节骨关节炎（OA）的发生和进展有关，但目前很少有数据证实其在早期 OA 中的存在。本研究旨在确定早期 OA 患者和无 OA 患者股四头肌功能障碍的存在及其严重程度。35 名女性志愿者根据是否存在（Kellgren-Lawrence [K-L] 分级 2）或不存在（K-L 分级 0-1）轻度 OA，分为 OA 组（n=22）和对照组（n=13）。采用单因素方差分析比较两组间等长股四头肌肌力和中枢激活比（CAR）。采用频率统计和 Fisher 确切概率法比较两组间存在和不存在 CAF 的女性百分比。存在轻度 OA 的女性股四头肌肌力（对照组：1.47+/-0.62 Nm/kg；OA 组：1.30+/-0.62 Nm/kg；p=0.45）与无 OA 者无显著差异。此外，两组间 CAR（对照组：0.91+/-0.07；OA 组：0.87+/-0.12；p=0.19）无差异；然而，两组女性均存在 CAF（对照组：54%；OA 组：73%；p=0.29）。我们的研究结果表明，患有轻度骨关节炎的女性不存在股四头肌功能障碍。
