Department of Physical Therapy, Center of Biological and Health Sciences, Federal University of São Carlos, Washington Luis Road, km 235, SP-310, São Carlos, SP, 13.565-905, Brazil.
Community and Allied Health Department, La Trobe University - Rural Health School, Bendigo, Victoria, Australia.
Clin Rheumatol. 2019 Sep;38(9):2603-2611. doi: 10.1007/s10067-019-04539-9. Epub 2019 Apr 23.
To investigate any differences in muscle architecture (fascicle angle, fascicle length, and muscle thickness) and muscle strength in people of different ages with and without knee osteoarthritis (OA).
This is a cross-sectional study conducted with 40 individuals with and 40 without knee OA. Four groups were analyzed, middle-aged OA group (KL II/III) aged 40-50 years (n = 20), middle-aged healthy (H) group aged 40-50 years (n = 20), older OA group (KL II/III) aged 70 years and over (n = 20), and older H group, aged 70 years and over (n = 20). Outcomes analyzed were isometric and isokinetic peak torque of knee extensors, level of physical activity, self-reported pain level, and vastus lateralis fascicle length, fascicle angle, and muscle thickness assessed by ultrasound. One-way ANOVA was used to identify differences between groups, followed by the Tukey post hoc test.
There were no differences between the middle-aged OA group and older H group for any variables. The older OA group presented the smallest muscle architecture parameters and worst isometric and concentric peak torques compared to the other three groups (p < 0.001). In contrast, the middle-aged H group presented the largest muscle architecture parameters and was the strongest group compared to the others (p < 0.001).
The presence of knee OA is associated with early muscular changes and seems to intensify these thigh changes that are similar to the effects of the aging process.
研究不同年龄、有无膝骨关节炎（OA）的人群的肌肉结构（肌束角、肌束长度和肌肉厚度）和肌肉力量是否存在差异。
这是一项横断面研究，共纳入 40 名膝骨关节炎患者和 40 名健康对照者。分析了 4 组人群，分别为中年膝骨关节炎组（KL II/III）年龄 40-50 岁（n=20）、中年健康组年龄 40-50 岁（n=20）、老年膝骨关节炎组（KL II/III）年龄 70 岁及以上（n=20）和老年健康组年龄 70 岁及以上（n=20）。分析的结果包括膝关节伸肌的等长和等速峰值扭矩、身体活动水平、自我报告的疼痛程度以及股外侧肌束长度、束角和肌肉厚度，均通过超声评估。采用单因素方差分析比较组间差异，然后进行 Tukey 事后检验。
中年膝骨关节炎组与老年健康组在任何变量上均无差异。与其他三组相比，老年膝骨关节炎组的肌肉结构参数最小，等长和向心峰值扭矩最差（p<0.001）。相比之下，中年健康组的肌肉结构参数最大，与其他三组相比，是最强的一组（p<0.001）。
膝骨关节炎的存在与早期肌肉变化有关，并且似乎加剧了这些类似于衰老过程影响的大腿变化。
