Lu Zhen Sui, Lu Zhen Hong, Lu Hang, Yan Shi Gui, Wang Jian An, Li Ling, You Wei
Department of Orthopedic Surgery, Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China.
Blood Press. 2009;18(5):268-72. doi: 10.3109/08037050903244783.
In this cross-sectional study, we examined whether hyperuricemia is associated with hypertension and the association exists in a Chinese population at a high risk of hypertension. The study population included 813 consecutively clinical patients with suspected cardiovascular disease, including the subjects with the current use of antihypertensive medications and self-reported diagnosis of hypertension. The subjects underwent three measures of blood pressure and were divided into two groups: 502 non-hypertensive subjects and 311 hypertensive subjects. Clinical and biochemical variables were measured. Results showed that uric acid level, fasting glucose, low-density lipoprotein (LDL)-cholesterol, total cholesterol and urea nitrogen were significantly higher (all p<0.05) in hypertension subjects than in non-hypertension subjects. The risk of hypertension was significantly higher in the group with higher uric acid (>400 micromol/l), compared with that with lower uric acid (<200 micromol/l) (odds ratio: 2.09, 95% CI 1.13-3.88). The odds ratio was 1.73, 95% CI 1.05-2.85 in the higher uric acid (200-400 micromol/l) group, compared with that with lower uric acid. In addition, age, gender, weight, fasting glucose, triglycerides and total cholesterol were also significantly associated with the incidence of hypertension. In age-adjusted logistic regression analysis, the effect of uric acid concentration on hypertension was attenuated. In conclusion, hyperuricemia is associated with hypertension in a Chinese population at a high risk of hypertension.
在这项横断面研究中，我们调查了高尿酸血症是否与高血压相关，以及这种关联是否存在于高血压高危的中国人群中。研究人群包括813例连续入选的疑似心血管疾病的临床患者，包括正在使用抗高血压药物和自我报告诊断为高血压的受试者。受试者接受了三次血压测量，并被分为两组：502例非高血压受试者和311例高血压受试者。测量了临床和生化变量。结果显示，高血压受试者的尿酸水平、空腹血糖、低密度脂蛋白（LDL）胆固醇、总胆固醇和尿素氮均显著高于非高血压受试者（均p<0.05）。尿酸水平较高（>400微摩尔/升）的组与尿酸水平较低（<200微摩尔/升）的组相比，高血压风险显著更高（优势比：2.09，95%CI 1.13-3.88）。尿酸水平在200-400微摩尔/升的较高尿酸组与较低尿酸组相比，优势比为1.73，95%CI 1.05-2.85。此外，年龄、性别、体重、空腹血糖、甘油三酯和总胆固醇也与高血压发病率显著相关。在年龄调整的逻辑回归分析中，尿酸浓度对高血压的影响减弱。总之，在高血压高危的中国人群中，高尿酸血症与高血压相关。
